| Literature DB >> 7648205 |
V Král1, E A Brucker, G Hemmi, J L Sessler, J Králová, H Bose.
Abstract
The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at microM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.Entities:
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Year: 1995 PMID： 7648205 DOI： 10.1016/0968-0896(95)00071-n
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641