Literature DB >> 7648165

Tissue factor expression correlates with histological grade in human pancreatic cancer.

A K Kakkar1, N R Lemoine, M F Scully, S Tebbutt, R C Williamson.   

Abstract

The transmembrane cellular receptor tissue factor (TF) is the primary initiator of the coagulation cascade in man. Expression of TF was determined in 55 specimens of ductal adenocarcinoma of the pancreas and was found to correlate strongly with the degree of histological differentiation. A significant linear trend was observed with stronger immunoreactivity observed in poorly differentiated tumours (chi 2 = 6.69, P = 0.0098). No TF staining was seen in pancreatic samples from normal controls (n = 18). As expression of TF may be associated with tumour progression, its analysis could provide useful prognostic information in patients with pancreatic malignancy.

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Year:  1995        PMID： 7648165     DOI： 10.1002/bjs.1800820831

Source DB:  PubMed          Journal:  Br J Surg        ISSN： 0007-1323            Impact factor:   6.939


  56 in total

1.  Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell.

Authors:  Zhi-Chao Jia; Yuan-Lian Wan; Jian-Qiang Tang; Yun Dai; Yu-Cun Liu; Xin Wang; Jing Zhu
Journal:  Int J Colorectal Dis       Date:  2011-11-12       Impact factor: 2.571

2.  Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma.

Authors:  Andreia Da Silva de Oliveira; Luize G Lima; Andréa Mariano-Oliveira; Daniel E Machado; Luiz E Nasciutti; John F Andersen; Lars C Petersen; Ivo M B Francischetti; Robson Q Monteiro
Journal:  Thromb Res       Date:  2012-06-09       Impact factor: 3.944

Review 3.  Thrombosis and cancer.

Authors:  Annie Young; Oliver Chapman; Carole Connor; Christopher Poole; Peter Rose; Ajay K Kakkar
Journal:  Nat Rev Clin Oncol       Date:  2012-07-10       Impact factor: 66.675

Review 4.  Venous thrombosis and cancer: from mouse models to clinical trials.

Authors:  Y Hisada; J E Geddings; C Ay; N Mackman
Journal:  J Thromb Haemost       Date:  2015-06-26       Impact factor: 5.824

5.  Pulmonary embolism and stroke as the initial manifestation of advanced metastatic pancreatic adenocarcinoma.

Authors:  Sudeep Dhoj Thapa; Hiba Hadid; Mohammad Usman
Journal:  J Gastrointest Cancer       Date:  2015-06

6.  Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets.

Authors:  Tessa Ys Le Large; Giulia Mantini; Laura L Meijer; Thang V Pham; Niccola Funel; Nicole Ct van Grieken; Bart Kok; Jaco Knol; Hanneke Wm van Laarhoven; Sander R Piersma; Connie R Jimenez; G Kazemier; Elisa Giovannetti; Maarten F Bijlsma
Journal:  JCI Insight       Date:  2020-08-06

7.  Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.

Authors:  J E Geddings; Y Hisada; Y Boulaftali; T M Getz; M Whelihan; R Fuentes; R Dee; B C Cooley; N S Key; A S Wolberg; W Bergmeier; N Mackman
Journal:  J Thromb Haemost       Date:  2015-12-11       Impact factor: 5.824

8.  The pro-migratory and pro-invasive role of the procoagulant tissue factor in malignant gliomas.

Authors:  Stephan Dützmann; Florian Gessler; Patrick N Harter; Rüdiger Gerlach; Michel Mittelbronn; Volker Seifert; Donat Kögel
Journal:  Cell Adh Migr       Date:  2010 Oct-Dec       Impact factor: 3.405

9.  Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration.

Authors:  Gertrud M Hjortoe; Lars C Petersen; Tatjana Albrektsen; Brit B Sorensen; Peder L Norby; Samir K Mandal; Usha R Pendurthi; L Vijaya Mohan Rao
Journal:  Blood       Date:  2004-01-08       Impact factor: 22.113

10.  Ixolaris, a tissue factor inhibitor, blocks primary tumor growth and angiogenesis in a glioblastoma model.

Authors:  T C Carneiro-Lobo; S Konig; D E Machado; L E Nasciutti; M F Forni; I M B Francischetti; M C Sogayar; R Q Monteiro
Journal:  J Thromb Haemost       Date:  2009-07-17       Impact factor: 5.824
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