Literature DB >> 7648028

The potential of ribozymes as antiviral agents.

G Sczakiel1, W Nedbal.   

Abstract

Ribozymes are promising tools for the specific inhibition of viral gene expression and replication. They represent one of the most attractive developments of antisense nucleic acids, which have been shown in the past few years to act as antiviral agents. Ribozymes not only complex with target sequences via complementary antisense sequences, but also hydrolyze the target site.

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Year:  1995        PMID： 7648028     DOI： 10.1016/s0966-842x(00)88927-1

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  7 in total

1.  Inhibition of hepatitis B virus X gene expression by novel DNA enzymes.

Authors:  R Goila; A C Banerjea
Journal:  Biochem J       Date:  2001-02-01       Impact factor: 3.857

2.  The efficiency of a cis-cleaving ribozyme in an mRNA coding region is influenced by the translating ribosome in vivo.

Authors:  S Zhang; M Stancek; L A Isaksson
Journal:  Nucleic Acids Res       Date:  1997-11-01       Impact factor: 16.971

3.  The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells.

Authors:  R Hormes; M Homann; I Oelze; P Marschall; M Tabler; F Eckstein; G Sczakiel
Journal:  Nucleic Acids Res       Date:  1997-02-15       Impact factor: 16.971

Review 4.  Positive and negative aspects of the human immunodeficiency virus protease: development of inhibitors versus its role in AIDS pathogenesis.

Authors:  K Ikuta; S Suzuki; H Horikoshi; T Mukai; R B Luftig
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

5.  RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts.

Authors:  M Scherr; J J Rossi; G Sczakiel; V Patzel
Journal:  Nucleic Acids Res       Date:  2000-07-01       Impact factor: 16.971

6.  Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells.

Authors:  J Beck; M Nassal
Journal:  Nucleic Acids Res       Date:  1995-12-25       Impact factor: 16.971

Review 7.  Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication.

Authors:  Kingshuk Panda; Kalichamy Alagarasu; Deepti Parashar
Journal:  Molecules       Date:  2021-02-11       Impact factor: 4.411
  7 in total

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