Structure and metabolism of lipoprotein (a).

An understanding of the complex structural and metabolic features of lipoprotein (a) is essential because this lipoprotein particle, with poorly recognized physiological functions, has been implicated in both thrombogenesis and atherogenesis. Studies aimed at investigating the structure-function relationship of apolipoprotein (a) have generated new useful information. In-vivo and in-vitro studies have provided insights into the synthesis, secretion, and association of apolipoprotein (a) with apolipoprotein B100 and the mechanisms regulating the lipoprotein (a) concentration in the bloodstream.