| Literature DB >> 7646569 |
L J Anghileri1, P Maincent, P Thouvenot.
Abstract
The role of cell calcium overload in the cardiotoxicity of low molecular weight iron complexes has been studied using 45Ca(2+)-uptake determinations in mice intraperitoneally injected with ferric lactate and ferric-ATP complex. Heart tissue shows a very high increase of 45Ca(2+)-uptake which appears to corroborate the hypothesis of cardiotoxicity by calcium overload. ATP seems to play a role in the degree of iron complex efficiency as cell calcium homeostasis modifier.Entities:
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Year: 1995 PMID： 7646569
Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172