Literature DB >> 7646477

A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.

M T Webster1, N Groome, P T Francis, B R Pearce, F E Sherriff, G Thinakaran, K M Felsenstein, W Wasco, R E Tanzi, D M Bowen.   

Abstract

A monoclonal antibody, 3B11, was raised to a novel protein, amyloid precursor-like protein 2, which did not recognize amyloid precursor protein. Multiple bands were detected in human brain fractions and cell lysate by Western blotting, indicating the presence of isoforms, 3B11 immunoreactivity was also detected in cerebrospinal fluid and conditioned medium, indicating that the protein is secreted. Immunocytochemistry revealed 3B11 immunoreactivity in sections of human brain.

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Year:  1995        PMID： 7646477      PMCID： PMC1135859          DOI： 10.1042/bj3100095

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

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5.  Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

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Authors:  A Weidemann; G König; D Bunke; P Fischer; J M Salbaum; C L Masters; K Beyreuther
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Authors:  R M Nitsch; B E Slack; R J Wurtman; J H Growdon
Journal:  Science       Date:  1992-10-09       Impact factor: 47.728

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Authors:  F E Sherriff; L R Bridges; P Jackson
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  7 in total

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7.  Matriptase processing of APLP1 ectodomain alters its homodimerization.

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  7 in total

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