Clinical and pathological features of highly malignant prostatic carcinomas with metastases to the penis.

Since 1885, 73 penile metastases of a primary carcinoma of the prostate have been reported. There is no standardized therapy as various therapeutic methods have produced variable results. The authors present their experiences with 2 recent cases. In some cases, total penectomy can relieve untolerable pain. Immunohistochemistry and flow cytometry for various prognostic factors showed a high malignant potential of carcinomas of the prostate metastasizing to the penis. Screening for various prognostic factors could favor an initial, more radical surgical approach in some cases, thus avoiding later tumor progression.