Literature DB >> 7644509

A molecular anchor for stabilizing triple-helical DNA.

K R Fox1, P Polucci, T C Jenkins, S Neidle.   

Abstract

Molecular modeling has been used to predict that 2,6-disubstituted amidoanthraquinones, and not the 1,4 series, should preferentially interact with and stabilize triple-stranded DNA structures over duplex DNA. This is due to marked differences in the nature of chromophore-base stacking and groove accessibility for the two series. A DNA foot-printing method that monitors the extent of protection from DNase I cleavage on triplex formation has been used to examine the effects of a number of synthetic isomer compounds in the 1,4 and 2,6 series. The experimental results are in accord with the predicted behavior and confirm that the 1,4 series bind preferentially to double- rather than triple-stranded DNA, whereas the isomeric 2,6 derivatives markedly favor binding to triplex DNA.

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Year:  1995        PMID： 7644509      PMCID： PMC41251          DOI： 10.1073/pnas.92.17.7887

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Molecular modeling to study DNA intercalation by anti-tumor drugs.

Authors:  S Neidle; T C Jenkins
Journal:  Methods Enzymol       Date:  1991       Impact factor: 1.600

Review 2.  DNA triplexes: solution structures, hydration sites, energetics, interactions, and function.

Authors:  I Radhakrishnan; D J Patel
Journal:  Biochemistry       Date:  1994-09-27       Impact factor: 3.162

3.  Sequence-specific cleavage of double helical DNA by triple helix formation.

Authors:  H E Moser; P B Dervan
Journal:  Science       Date:  1987-10-30       Impact factor: 47.728

4.  Effect of a triplex-binding ligand on parallel and antiparallel DNA triple helices using short unmodified and acridine-linked oligonucleotides.

Authors:  S A Cassidy; L Strekowski; W D Wilson; K R Fox
Journal:  Biochemistry       Date:  1994-12-27       Impact factor: 3.162

5.  Site-specific targeting of psoralen photoadducts with a triple helix-forming oligonucleotide: characterization of psoralen monoadduct and crosslink formation.

Authors:  F P Gasparro; P A Havre; G A Olack; E J Gunther; P M Glazer
Journal:  Nucleic Acids Res       Date:  1994-07-25       Impact factor: 16.971

6.  DNase I footprinting of triple helix formation at polypurine tracts by acridine-linked oligopyrimidines: stringency, structural changes and interaction with minor groove binding ligands.

Authors:  T J Stonehouse; K R Fox
Journal:  Biochim Biophys Acta       Date:  1994-08-02

7.  Triplex formation by the human Ha-ras promoter inhibits Sp1 binding and in vitro transcription.

Authors:  C Mayfield; S Ebbinghaus; J Gee; D Jones; B Rodu; M Squibb; D Miller
Journal:  J Biol Chem       Date:  1994-07-08       Impact factor: 5.157

8.  Triple helix formation inhibits transcription elongation in vitro.

Authors:  S L Young; S H Krawczyk; M D Matteucci; J J Toole
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

9.  Binding of triple helix forming oligonucleotides to sites in gene promoters.

Authors:  R H Durland; D J Kessler; S Gunnell; M Duvic; B M Pettitt; M E Hogan
Journal:  Biochemistry       Date:  1991-09-24       Impact factor: 3.162

10.  Ligand-induced formation of nucleic acid triple helices.

Authors:  D S Pilch; K J Breslauer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-27       Impact factor: 11.205
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  9 in total

1.  DNA sequence specificity of a naphthylquinoline triple helix-binding ligand.

Authors:  S A Cassidy; L Strekowski; K R Fox
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

2.  Stabilisation of TG- and AG-containing antiparallel DNA triplexes by triplex-binding ligands.

Authors:  M D Keppler; S Neidle; K R Fox
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  Complete disproportionation of duplex poly(dT)*poly(dA) into triplex poly(dT)*poly(dA)*poly(dT) and poly(dA) by coralyne.

Authors:  Matjaz Polak; Nicholas V Hud
Journal:  Nucleic Acids Res       Date:  2002-02-15       Impact factor: 16.971

4.  Triple helices formed at oligopyrimidine*oligopurine sequences with base pair inversions: effect of a triplex-specific ligand on stability and selectivity.

Authors:  S Kukreti; J S Sun; D Loakes; D M Brown; C H Nguyen; E Bisagni; T Garestier; C Helene
Journal:  Nucleic Acids Res       Date:  1998-05-01       Impact factor: 16.971

5.  Relative stability of triplexes containing different numbers of T.AT and C+.GC triplets.

Authors:  M D Keppler; K R Fox
Journal:  Nucleic Acids Res       Date:  1997-11-15       Impact factor: 16.971

6.  Rational design of a triple helix-specific intercalating ligand.

Authors:  C Escudé; C H Nguyen; S Kukreti; Y Janin; J S Sun; E Bisagni; T Garestier; C Hélène
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-31       Impact factor: 11.205

Review 7.  Modulation of DNA structure formation using small molecules.

Authors:  Imee M A Del Mundo; Karen M Vasquez; Guliang Wang
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2019-09-03       Impact factor: 4.739

8.  Triplex formation at physiological pH by 5-Me-dC-N4-(spermine) [X] oligodeoxynucleotides: non protonation of N3 in X of X*G:C triad and effect of base mismatch/ionic strength on triplex stabilities.

Authors:  D A Barawkar; K G Rajeev; V A Kumar; K N Ganesh
Journal:  Nucleic Acids Res       Date:  1996-04-01       Impact factor: 16.971

9.  Disordering of human telomeric G-quadruplex with novel antiproliferative anthrathiophenedione.

Authors:  Dmitry Kaluzhny; Nikolay Ilyinsky; Andrei Shchekotikhin; Yuri Sinkevich; Philipp O Tsvetkov; Vladimir Tsvetkov; Alexander Veselovsky; Mikhail Livshits; Olga Borisova; Alexander Shtil; Anna Shchyolkina
Journal:  PLoS One       Date:  2011-11-15       Impact factor: 3.240
  9 in total

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