Literature DB >> 7644503

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.

R Taneja1, P Bouillet, J F Boylan, M P Gaub, B Roy, L J Gudas, P Chambon.   

Abstract

Disruption of retinoic acid receptor (RAR) gamma in F9 embryonal carcinoma cells leads to aberrent differentiation and reduced activation of expression of several all-trans-retinoic acid (RA)-induced genes. We have analyzed the expression of several additional RA-responsive genes in RAR alpha- and RAR gamma-null F9 cells. The RA-induced activation of Cdx1, Gap43, Stra4, and Stra6 was specifically impaired in RAR gamma-null cells, supporting the idea that each RAR may regulate distinct subsets of target genes. To further investigate the role of RAR gamma in F9 cell differentiation, "rescue" cell lines reexpressing RAR gamma 2 or overexpressing either RAR alpha 1 or RAR beta 2 were established in RAR gamma-null cells. Reexpression of RAR gamma or overexpression of RAR alpha restored both target-gene activation and the differentiation potential. In contrast, over-expression of RAR beta only poorly restored differentiation, although it could replace RAR gamma for the activation of target genes. Functional redundancy between the various RARs is discussed.

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Year:  1995        PMID： 7644503      PMCID： PMC41244          DOI： 10.1073/pnas.92.17.7854

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternate splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox.

Authors:  G J LaRosa; L J Gudas
Journal:  Mol Cell Biol       Date:  1988-09       Impact factor: 4.272

2.  Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression.

Authors:  T Lufkin; A Dierich; M LeMeur; M Mark; P Chambon
Journal:  Cell       Date:  1991-09-20       Impact factor: 41.582

3.  A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

Authors:  M A Pratt; J Kralova; M W McBurney
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

4.  Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene.

Authors:  H de Thé; M M Vivanco-Ruiz; P Tiollais; H Stunnenberg; A Dejean
Journal:  Nature       Date:  1990-01-11       Impact factor: 49.962

5.  Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.

Authors:  O Chisaka; T S Musci; M R Capecchi
Journal:  Nature       Date:  1992-02-06       Impact factor: 49.962

6.  Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter.

Authors:  C N Adra; P H Boer; M W McBurney
Journal:  Gene       Date:  1987       Impact factor: 3.688

7.  Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism.

Authors:  J F Boylan; T Lufkin; C C Achkar; R Taneja; P Chambon; L J Gudas
Journal:  Mol Cell Biol       Date:  1995-02       Impact factor: 4.272

8.  Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

Authors:  S J Collins; K A Robertson; L Mueller
Journal:  Mol Cell Biol       Date:  1990-05       Impact factor: 4.272

9.  A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system.

Authors:  M M Garner; A Revzin
Journal:  Nucleic Acids Res       Date:  1981-07-10       Impact factor: 16.971

10.  Retinoic acid receptor gamma: specific immunodetection and phosphorylation.

Authors:  C Rochette-Egly; Y Lutz; M Saunders; I Scheuer; M P Gaub; P Chambon
Journal:  J Cell Biol       Date:  1991-10       Impact factor: 10.539
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  28 in total

1.  Retinoic acid regulation of Cdx1: an indirect mechanism for retinoids and vertebral specification.

Authors:  M Houle; P Prinos; A Iulianella; N Bouchard; D Lohnes
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma.

Authors:  J C Xue; E J Schwarz; A Chawla; M A Lazar
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

3.  Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.

Authors:  R Taneja; B Roy; J L Plassat; C F Zusi; J Ostrowski; P R Reczek; P Chambon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

4.  Phosphorylation of activation functions AF-1 and AF-2 of RAR alpha and RAR gamma is indispensable for differentiation of F9 cells upon retinoic acid and cAMP treatment.

Authors:  R Taneja; C Rochette-Egly; J L Plassat; L Penna; M P Gaub; P Chambon
Journal:  EMBO J       Date:  1997-11-03       Impact factor: 11.598

5.  Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.

Authors:  Kristian B Laursen; Lorraine J Gudas
Journal:  J Biol Chem       Date:  2018-05-30       Impact factor: 5.157

6.  Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage.

Authors:  S Carrera; S Cuadrado-Castano; J Samuel; G D D Jones; E Villar; S W Lee; S Macip
Journal:  Cell Death Differ       Date:  2013-03-01       Impact factor: 15.828

7.  Retinoic acid receptor-mediated induction of ABCA1 in macrophages.

Authors:  Philippe Costet; Florent Lalanne; Marie C Gerbod-Giannone; Jennifer R Molina; Xuan Fu; Erik G Lund; Lorraine J Gudas; Alan R Tall
Journal:  Mol Cell Biol       Date:  2003-11       Impact factor: 4.272

8.  Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells.

Authors:  Dan Su; Lorraine J Gudas
Journal:  Biochem Pharmacol       Date:  2007-11-22       Impact factor: 5.858

9.  Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment.

Authors:  Trisha S Tavares; David Nanus; Ximing J Yang; Lorraine J Gudas
Journal:  Cancer Biol Ther       Date:  2008-10-09       Impact factor: 4.742

Review 10.  Function of retinoic acid receptors during embryonic development.

Authors:  Manuel Mark; Norbert B Ghyselinck; Pierre Chambon
Journal:  Nucl Recept Signal       Date:  2009-04-03
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