| Literature DB >> 7643989 |
J P Sutton1, W Couldwell, M F Lew, L Mallory, S Grafton, C DeGiorgio, M Welsh, M L Apuzzo, J Ahmadi, C H Waters.
Abstract
In a preliminary study, the effects of ventroposterior medial pallidotomy were evaluated in five patients with advanced Parkinson's disease in whom medical therapy had failed. The mean age was 67.0 +/- 5.6 years, and the mean Hoehn and Yahr stage when "off" was 3.9 +/- 1.3. Three patients received unilateral pallidotomies; two of these received another pallidotomy after 8 weeks. Two other patients received staged bilateral pallidotomies. No significant differences in overall function could be seen before and after the first surgical procedure. All three patients with peak-dose dyskinesias or dystonia had marked contralateral reduction in these symptoms. Ventroposterior medial pallidotomy can ameliorate peak-dose dyskinesias in patients with advanced Parkinson's disease. Overall function improvement is not remarkable.Entities:
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Year: 1995 PMID: 7643989 DOI: 10.1227/00006123-199506000-00007
Source DB: PubMed Journal: Neurosurgery ISSN: 0148-396X Impact factor: 4.654