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Literature DB >> 7643351

Leukaemia and Sellafield: is there a heritable link?

Abstract

The demonstration of a statistical association between paternal preconceptional irradiation and childhood leukaemia appeared to provide a satisfactory explanation for the excess of cases in the village of Seascale, close to the Sellafield nuclear installation, and became the basis of two legal claims for compensation. In the ensuing scientific debate the biological plausibility of a causal interpretation of this association focused on the heritability of leukaemia and a comparison of the genetic risks implied by this finding with current information on the induction of genetic damage by irradiation. After a wide ranging review of the mechanistic issues it is concluded that there is no genetic basis for a causal relationship and this, together with recent appraisals of epidemiological studies, suggests that the association between childhood leukaemia and paternal preconceptional irradiation exposure is most likely to be a chance finding.

Entities: Disease

Mesh：

Year: 1995 PMID： 7643351 PMCID： PMC1050370 DOI： 10.1136/jmg.32.4.251

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

37 in total

1. Follow up study of children born to mothers resident in Seascale, West Cumbria (birth cohort).

Authors: M J Gardner; A J Hall; S Downes; J D Terrell
Journal: Br Med J (Clin Res Ed) Date: 1987-10-03

2. A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity.

Authors: S M Huson; D A Compston; P Clark; P S Harper
Journal: J Med Genet Date: 1989-11 Impact factor: 6.318

3. No statistical association between common fragile sites and nonrandom chromosome breakpoints in cancer cells.

Authors: G R Sutherland; R N Simmers
Journal: Cancer Genet Cytogenet Date: 1988-03

Review 4. A review of the risks of leukemia in relation to parental pre-conception exposure to radiation.

Authors: M P Little; M W Charles; R Wakeford
Journal: Health Phys Date: 1995-03 Impact factor: 1.316

5. Cancer among 1,348 offspring of survivors of childhood cancer.

Authors: M M Hawkins; G J Draper; R A Smith
Journal: Int J Cancer Date: 1989-06-15 Impact factor: 7.396

6. Cancer in relatives of leukemic patients with chromosomal rearrangements at rare (heritable) fragile-site locations in their malignant cells.

Authors: E H Mules; J R Testa; G H Thomas; H Abbey; B H Cohen
Journal: Am J Hum Genet Date: 1989-06 Impact factor: 11.025

4. The Likelihood of Adverse Pregnancy Outcomes and Genetic Disease (Transgenerational Effects) from Exposure to Radioactive Fallout from the 1945 Trinity Atomic Bomb Test.

Authors: John D Boice
Journal: Health Phys Date: 2020-10 Impact factor: 2.922

4 in total

Leukaemia and Sellafield: is there a heritable link?

1. Follow up study of children born to mothers resident in Seascale, West Cumbria (birth cohort).

2. A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity.

3. No statistical association between common fragile sites and nonrandom chromosome breakpoints in cancer cells.

Review 4. A review of the risks of leukemia in relation to parental pre-conception exposure to radiation.

5. Cancer among 1,348 offspring of survivors of childhood cancer.

6. Cancer in relatives of leukemic patients with chromosomal rearrangements at rare (heritable) fragile-site locations in their malignant cells.

7. Cancer in offspring of long-term survivors of childhood and adolescent cancer.

8. The risk of leukemia in Seascale from radiation exposure.

9. Occurrence of childhood cancers among sibs and estimation of familial risks.

10. Obstetric outcomes in West Cumberland Hospital: is there a risk from Sellafield?

1. Leukaemia and Sellafield: is there a heritable link?

2. Genetic studies at the Atomic Bomb Casualty Commission-Radiation Effects Research Foundation: 1946-1997.

3. New approaches to evaluating the genetic effects of the atomic bombs.

4. The Likelihood of Adverse Pregnancy Outcomes and Genetic Disease (Transgenerational Effects) from Exposure to Radioactive Fallout from the 1945 Trinity Atomic Bomb Test.