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Literature DB >> 7642351

An experimental model of progressive epilepsy: the development of kindling of the hippocampus of the rat.

F H Lopes da Silva¹, W Kamphuis, M Titulaer, M Vreugdenhil, W J Wadman.

Abstract

Kindling epileptogenesis was induced by periodic electrical stimulation of the Schaffer collateral/commissural pathway in the CA1 area of the rat hippocampus. The progressive nature of hippocampal kindling is demonstrated by a detailed description of the behavioral signs and the progressive increase of the after-discharge duration in the course of kindling acquisition. Furthermore, the evolution of the alterations in the paired-pulse local evoked field potentials and the modifications of the GABAA receptor binding and of the expression of mRNAs encoding for the subunits of the GABAA and glutamate receptors are considered. Evidence is presented that during kindling opposite changes occur in the CA1 and the fascia dentata in terms of the balance between excitation and inhibition due to contrasting changes in GABA-mediated inhibitory function.

Entities: Chemical Disease Gene Species

Mesh：

Year: 1995 PMID： 7642351 DOI： 10.1007/bf02229074

Source DB: PubMed Journal: Ital J Neurol Sci ISSN： 0392-0461

42 in total

Review 1. Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region.

Authors: M P Witter; H J Groenewegen; F H Lopes da Silva; A H Lohman
Journal: Prog Neurobiol Date: 1989 Impact factor: 11.685

2. Quantitative autoradiographic analysis of the [3H]muscimol binding in the kindled rat hippocampus: time-dependent and regional specific changes.

Authors: M N Titulaer; W Kamphuis; F H Lopes da Silva
Journal: Epilepsy Res Suppl Date: 1996

3. Immunocytochemical study of GABAergic neurons containing the calcium-binding protein parvalbumin in the rat hippocampus.

Authors: H Katsumaru; T Kosaka; C W Heizmann; K Hama
Journal: Exp Brain Res Date: 1988 Impact factor: 1.972

4. Alteration in dentate neuronal activities associated with perforant path kindling. II. Decrease in granule cell excitability.

Authors: E Maru; G V Goddard
Journal: Exp Neurol Date: 1987-04 Impact factor: 5.330

5. Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents.

Authors: T S Otis; Y De Koninck; I Mody
Journal: Proc Natl Acad Sci U S A Date: 1994-08-02 Impact factor: 11.205

6. Development of epileptic seizures through brain stimulation at low intensity.

Authors: G V Goddard
Journal: Nature Date: 1967-06-03 Impact factor: 49.962

7. Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. I. Effects on linear and non-linear response characteristics.

Authors: G B Robinson; R J Sclabassi; T W Berger
Journal: Brain Res Date: 1991-10-18 Impact factor: 3.252

8. Kindling induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity.

Authors: W Kamphuis; E Huisman; W J Wadman; C W Heizmann; F H Lopes da Silva
Journal: Brain Res Date: 1989-02-06 Impact factor: 3.252

2. Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.

Authors: F Liang; E G Jones
Journal: J Neurosci Date: 1997-03-15 Impact factor: 6.167

An experimental model of progressive epilepsy: the development of kindling of the hippocampus of the rat.

Review 1. Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region.

2. Quantitative autoradiographic analysis of the [3H]muscimol binding in the kindled rat hippocampus: time-dependent and regional specific changes.

3. Immunocytochemical study of GABAergic neurons containing the calcium-binding protein parvalbumin in the rat hippocampus.

4. Alteration in dentate neuronal activities associated with perforant path kindling. II. Decrease in granule cell excitability.

5. Lasting potentiation of inhibition is associated with an increased number of gamma-aminobutyric acid type A receptors activated during miniature inhibitory postsynaptic currents.

6. Development of epileptic seizures through brain stimulation at low intensity.

7. Kindling-induced potentiation of excitatory and inhibitory inputs to hippocampal dentate granule cells. I. Effects on linear and non-linear response characteristics.

8. Kindling induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity.

9. Enhancement of recurrent inhibition by angular bundle kindling is retained in hippocampal slices.

10. Activation of protein kinase C selectively inhibits the gamma-aminobutyric acidA receptor: role of desensitization.

1. Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performance.

2. Differential and time-dependent changes in gene expression for type II calcium/calmodulin-dependent protein kinase, 67 kDa glutamic acid decarboxylase, and glutamate receptor subunits in tetanus toxin-induced focal epilepsy.

3. Improving cognitive task in kindled rats by using low frequency stimulation during epileptogenesis.

Review 4. Critical evaluation of animal models for localization-related epilepsies.

Review 5. Maladaptive neural synchrony in tinnitus: origin and restoration.