V Vetter1, Y S Shin. 1. Universitäts-Klinik für Kinder und Jugendliche, Erlangen, Germany.
Abstract
UNLABELLED: Lens sorbitol dehydrogenase activity was assayed in patients with congenital cataracts, senile cataracts, without cataracts and in one fetal lens. In patients with congenital cataracts we did not observe any abnormality of galactose and sorbitol metabolising enzymes in erythrocytes. In one of these patients with inexplicable congenital cataracts lens sorbitol dehydrogenase deficiency was found. CONCLUSION: Determination of galactose metabolising enzymes, sorbitol dehydrogenase and polyols in lenses may help in understanding the mechanism of formation of inexplicable congenital cataracts.
UNLABELLED: Lens sorbitol dehydrogenase activity was assayed in patients with congenital cataracts, senile cataracts, without cataracts and in one fetal lens. In patients with congenital cataracts we did not observe any abnormality of galactose and sorbitol metabolising enzymes in erythrocytes. In one of these patients with inexplicable congenital cataracts lens sorbitol dehydrogenase deficiency was found. CONCLUSION: Determination of galactose metabolising enzymes, sorbitol dehydrogenase and polyols in lenses may help in understanding the mechanism of formation of inexplicable congenital cataracts.
Authors: A F Winder; L J Claringbold; R B Jones; B S Jay; N S Rice; R D Kissun; I S Menzies; J N Mount Journal: Arch Dis Child Date: 1983-05 Impact factor: 3.791
Authors: G Vaca; B Ibarra; M Bracamontes; D García-Cruz; J Sánchez-Corona; C Medina; C Wunsch; G González-Quiroga; J M Cantú Journal: Hum Genet Date: 1982 Impact factor: 4.132