| Literature DB >> 7638871 |
Y T Fu1, F S He, S L Zhang, J S Zhang.
Abstract
Using an electron spin resonance technique, free radical signals were observed to be increased in liver of rats 15, 30 and 45 min after orally dosing with 80 mg/kg 3-nitropropionic acid (3-NPA). Concentrations of 3-NPA from 595 to 2380 mg/litre enhanced the formation of adrenochrome from adrenaline in mitochondria and microsome suspensions of liver and brain. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) as well as the content of malonidialdehyde (MDA) were significantly increased in liver of rats dosed with 80 mg/kg 3-NPA. There was also a cerebral increase of activity of SOD and content of MDA. These results suggest that 3-NPA is able to produce lipid peroxidation both in vivo and in vitro.Entities:
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Year: 1995 PMID： 7638871 DOI： 10.1016/0041-0101(94)00173-6
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033