Literature DB >> 7637804

Modulation of memory fields by dopamine D1 receptors in prefrontal cortex.

G V Williams1, P S Goldman-Rakic.   

Abstract

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

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Year:  1995        PMID： 7637804     DOI： 10.1038/376572a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  443 in total

1.  A neurocomputational theory of the dopaminergic modulation of working memory functions.

Authors:  D Durstewitz; M Kelc; O Güntürkün
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

2.  The role of D1-dependent dopaminergic mechanisms of the frontal cortex in delayed responding in rats.

Authors:  A P Kozlov; M Y Druzin; N P Kurzina; E P Malinina
Journal:  Neurosci Behav Physiol       Date:  2001 Jul-Aug

3.  Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition.

Authors:  N Brunel; X J Wang
Journal:  J Comput Neurosci       Date:  2001 Jul-Aug       Impact factor: 1.621

4.  The physiological role of 5-HT2A receptors in working memory.

Authors:  Graham V Williams; Srinivas G Rao; Patricia S Goldman-Rakic
Journal:  J Neurosci       Date:  2002-04-01       Impact factor: 6.167

5.  The effects of dopamine D(1) receptor blockade in the prelimbic-infralimbic areas on behavioral flexibility.

Authors:  Michael E Ragozzino
Journal:  Learn Mem       Date:  2002 Jan-Feb       Impact factor: 2.460

6.  Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex.

Authors:  Nathaniel N Urban; Guillermo González-Burgos; Darrell A Henze; David A Lewis; German Barrionuevo
Journal:  J Physiol       Date:  2002-03-15       Impact factor: 5.182

7.  Persistence and brain circuitry.

Authors:  Debra A Gusnard; John M Ollinger; Gordon L Shulman; C Robert Cloninger; Joseph L Price; David C Van Essen; Marcus E Raichle
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-07       Impact factor: 11.205

8.  Neural activity in prefrontal cortex during copying geometrical shapes. II. Decoding shape segments from neural ensembles.

Authors:  Bruno B Averbeck; David A Crowe; Matthew V Chafee; Apostolos P Georgopoulos
Journal:  Exp Brain Res       Date:  2003-04-01       Impact factor: 1.972

Review 9.  Dopamine tunes prefrontal outputs to orchestrate aversive processing.

Authors:  Caitlin M Vander Weele; Cody A Siciliano; Kay M Tye
Journal:  Brain Res       Date:  2018-12-01       Impact factor: 3.252

10.  Characterization of PF-6142, a Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman Primate Models of Dopaminergic Activation.

Authors:  Rouba Kozak; Tamás Kiss; Keith Dlugolenski; David E Johnson; Roxanne R Gorczyca; Kyle Kuszpit; Brian D Harvey; Polina Stolyar; Stacey J Sukoff Rizzo; William E Hoffmann; Dmitri Volfson; Mihaly Hajós; Jennifer E Davoren; Amanda L Abbott; Graham V Williams; Stacy A Castner; David L Gray
Journal:  Front Pharmacol       Date:  2020-07-07       Impact factor: 5.810
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