Literature DB >> 7637690

Parasitism and chromosome dynamics in protozoan parasites: is there a connection?

M Lanzer1, K Fischer, S M Le Blancq.   

Abstract

Genomic plasticity is a hallmark of many protozoan parasites, including Plasmodium spp, Trypanosoma spp, Leishmania ssp and Giardia lamblia. Strikingly, there is a common theme regarding the structural basis of this karyotype variability. Chromosomes are compartmentalized into conserved central domains and polymorphic chromosome ends. Since antigen-encoding genes frequently reside in telomere-proximal domains, it is tempting to speculate that the genetic flexibility of chromosome ends has been recruited as a tool in immune evasion strategies by some parasitic protozoa.

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Year:  1995        PMID： 7637690     DOI： 10.1016/0166-6851(95)00021-r

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  20 in total

1.  Concerted evolution at a multicopy locus in the protozoan parasite Theileria parva: extreme divergence of potential protein-coding sequences.

Authors:  R Bishop; A Musoke; S Morzaria; B Sohanpal; E Gobright
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

2.  Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.

Authors:  M Cross; M C Taylor; P Borst
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

3.  The abundance of sterile transcripts in Giardia lamblia.

Authors:  H G Elmendorf; S M Singer; T E Nash
Journal:  Nucleic Acids Res       Date:  2001-11-15       Impact factor: 16.971

4.  A polymorphic multigene family encoding an immunodominant protein from Babesia microti.

Authors:  M J Homer; E S Bruinsma; M J Lodes; M H Moro; S Telford; P J Krause; L D Reynolds; R Mohamath; D R Benson; R L Houghton; S G Reed; D H Persing
Journal:  J Clin Microbiol       Date:  2000-01       Impact factor: 5.948

5.  Expression of var genes located within polymorphic subtelomeric domains of Plasmodium falciparum chromosomes.

Authors:  K Fischer; P Horrocks; M Preuss; J Wiesner; S Wünsch; A A Camargo; M Lanzer
Journal:  Mol Cell Biol       Date:  1997-07       Impact factor: 4.272

6.  Telomerase in kinetoplastid parasitic protozoa.

Authors:  M I Cano; J M Dungan; N Agabian; E H Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

7.  Structure of a frequently rearranged rRNA-encoding chromosome in Giardia lamblia.

Authors:  G Hou; S M Le Blancq; Y E; H Zhu; M G Lee
Journal:  Nucleic Acids Res       Date:  1995-08-25       Impact factor: 16.971

8.  Targeted terminal deletions as a tool for functional genomics studies in Plasmodium.

Authors:  T Pace; R Scotti; C J Janse; A P Waters; C Birago; M Ponzi
Journal:  Genome Res       Date:  2000-09       Impact factor: 9.043

9.  The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes.

Authors:  J P Rubio; J K Thompson; A F Cowman
Journal:  EMBO J       Date:  1996-08-01       Impact factor: 11.598

10.  The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species.

Authors:  P Wincker; C Ravel; C Blaineau; M Pages; Y Jauffret; J P Dedet; P Bastien
Journal:  Nucleic Acids Res       Date:  1996-05-01       Impact factor: 16.971
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