J A Connolly1, B Miller, P N Bretan. 1. Department of Urology, University of California School of Medicine, San Francisco, USA.
Abstract
PURPOSE: We assessed the long-term efficacy of renal transplantation in patients with posterior urethral valves. MATERIALS AND METHODS: We reviewed the outcome in 23 patients with posterior urethral valves who underwent renal transplantation since 1979. RESULTS: Graft survival was 69% at 5 years and 63% at 10 years. Seven patients with followup of 7 years or longer had a mean serum creatinine level of 1.5 mg/dl. Three patients (13%) demonstrated significant bladder dysfunction postoperatively. CONCLUSIONS: Renal transplantation into a valve bladder is not associated with an abnormally high rate of failure. Deterioration of graft function secondary to lower urinary tract dysfunction is uncommon, with the majority of patients able to use the unmodified native bladder as a receptacle for the transplanted kidney.
PURPOSE: We assessed the long-term efficacy of renal transplantation in patients with posterior urethral valves. MATERIALS AND METHODS: We reviewed the outcome in 23 patients with posterior urethral valves who underwent renal transplantation since 1979. RESULTS: Graft survival was 69% at 5 years and 63% at 10 years. Seven patients with followup of 7 years or longer had a mean serum creatinine level of 1.5 mg/dl. Three patients (13%) demonstrated significant bladder dysfunction postoperatively. CONCLUSIONS: Renal transplantation into a valve bladder is not associated with an abnormally high rate of failure. Deterioration of graft function secondary to lower urinary tract dysfunction is uncommon, with the majority of patients able to use the unmodified native bladder as a receptacle for the transplanted kidney.
Authors: Santiago Mendizabal; Isabel Zamora; Agustin Serrano; Maria Jose Sanahuja; Ezena Roman; Carlos Dominguez; Pedro Ortega; Fernando García Ibarra Journal: Pediatr Nephrol Date: 2006-02-21 Impact factor: 3.714