PURPOSE: The effects of smoking on testicular function and sperm physiology were studied. MATERIALS AND METHODS: Left testicular biopsy was performed in 49 smokers and 28 nonsmokers. Seminal specimens from these men were analyzed. RESULTS: Testosterone levels in the left testicular vein, left testicular androgen-binding protein secretion rate (in vitro), sperm motility, percentage of morphologically normal spermatozoa, sperm morphometric parameters and outcome of sperm function tests were significantly lower (p < 0.05) in smokers than in nonsmokers. CONCLUSIONS: Morphological sperm abnormalities due to secretory dysfunction of the Leydig and Sertoli cells may be the cause of impaired sperm fertilizing capacity in smokers.
PURPOSE: The effects of smoking on testicular function and sperm physiology were studied. MATERIALS AND METHODS: Left testicular biopsy was performed in 49 smokers and 28 nonsmokers. Seminal specimens from these men were analyzed. RESULTS:Testosterone levels in the left testicular vein, left testicular androgen-binding protein secretion rate (in vitro), sperm motility, percentage of morphologically normal spermatozoa, sperm morphometric parameters and outcome of sperm function tests were significantly lower (p < 0.05) in smokers than in nonsmokers. CONCLUSIONS: Morphological sperm abnormalities due to secretory dysfunction of the Leydig and Sertoli cells may be the cause of impaired sperm fertilizing capacity in smokers.
Authors: Kenan Omurtag; Prabagaran Esakky; Brian J Debosch; Erica L Schoeller; Maggie M Chi; Kelle H Moley Journal: Reprod Sci Date: 2014-05-06 Impact factor: 3.060
Authors: Anil K Rengan; Ashok Agarwal; Michelle van der Linde; Stefan S du Plessis Journal: Reprod Biol Endocrinol Date: 2012-11-17 Impact factor: 5.211