Literature DB >> 7636999

The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells.

M A Calenoff1, C S Badshah, M C Dal Canto, H L Lipton, M K Rundell.   

Abstract

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

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Year:  1995        PMID： 7636999      PMCID： PMC189406     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Authors:  A E Pritchard; M A Calenoff; S Simpson; K Jensen; H L Lipton
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

2.  Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus.

Authors:  W P Kong; R P Roos
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

3.  The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulence.

Authors:  H L Lipton; M Calenoff; P Bandyopadhyay; S D Miller; M C Dal Canto; S Gerety; K Jensen
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

4.  Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses.

Authors:  M Rodriguez; R P Roos
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

5.  Polyprotein processing of Theiler's murine encephalomyelitis virus.

Authors:  R P Roos; W P Kong; B L Semler
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

6.  Strains from both Theiler's virus subgroups encode a determinant for demyelination.

Authors:  J Fu; M Rodriguez; R P Roos
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

7.  Genomic regions of neurovirulence and attenuation in Theiler murine encephalomyelitis virus.

Authors:  M A Calenoff; K S Faaberg; H L Lipton
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

8.  Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system virus titers in inbred mouse strains.

Authors:  R J Clatch; H L Lipton; S D Miller
Journal:  Microb Pathog       Date:  1987-11       Impact factor: 3.738

9.  Neurovirulence determinants of genetically engineered Theiler viruses.

Authors:  J L Fu; S Stein; L Rosenstein; T Bodwell; M Routbort; B L Semler; R P Roos
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

10.  Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection.

Authors:  A Zurbriggen; C Thomas; M Yamada; R P Roos; R S Fujinami
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103
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  18 in total

1.  The leader polypeptide of Theiler's murine encephalomyelitis virus is required for the assembly of virions in mouse L cells.

Authors:  C Badshah; M A Calenoff; K Rundell
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway.

Authors:  Spyridon Stavrou; Zongdi Feng; Stanley M Lemon; Raymond P Roos
Journal:  J Virol       Date:  2010-07-07       Impact factor: 5.103

3.  The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response.

Authors:  Teresa de Los Santos; Sonia de Avila Botton; Rudi Weiblen; Marvin J Grubman
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

4.  Different subcellular localization of Theiler's murine encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells.

Authors:  Naoko Taniura; Mineki Saito; Takako Okuwa; Kousuke Saito; Yoshiro Ohara
Journal:  J Virol       Date:  2009-04-22       Impact factor: 5.103

5.  The neurovirulence of the DA and GDVII strains of Theiler's virus correlates with their ability To infect cultured neurons.

Authors:  N Jarousse; S Syan; C Martinat; M Brahic
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

6.  Protein 2A is not required for Theiler's virus replication.

Authors:  T Michiels; V Dejong; R Rodrigus; C Shaw-Jackson
Journal:  J Virol       Date:  1997-12       Impact factor: 5.103

7.  Nucleocytoplasmic traffic disorder induced by cardioviruses.

Authors:  Peter V Lidsky; Stanleyson Hato; Maryana V Bardina; Alexei G Aminev; Ann C Palmenberg; Eugene V Sheval; Vladimir Y Polyakov; Frank J M van Kuppeveld; Vadim I Agol
Journal:  J Virol       Date:  2006-03       Impact factor: 5.103

8.  The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon production.

Authors:  V van Pesch; O van Eyll; T Michiels
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

9.  Aichi virus leader protein is involved in viral RNA replication and encapsidation.

Authors:  Jun Sasaki; Shigeo Nagashima; Koki Taniguchi
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

10.  Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein.

Authors:  Lyudmila I Romanova; Peter V Lidsky; Marina S Kolesnikova; Ksenia V Fominykh; Anatoly P Gmyl; Eugene V Sheval; Stanleyson V Hato; Frank J M van Kuppeveld; Vadim I Agol
Journal:  J Virol       Date:  2009-05-06       Impact factor: 5.103
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