V De Vita1. 1. Divisione di Ostetricia e Ginecologia, Ospedale di Massafra, Taranto.
Abstract
OBJECTIVE: To evaluate the efficacy and tolerability of treatment with goserelin + HMG vs bromocriptine + FSH + HMG in the induction of ovulation in patients with ovarian polycystosis. EXPERIMENTAL DESIGN: A randomized prospective study. PATIENTS: Sterile women with ovarian polycystosis of the first type not responding to clomiphene citrate. TREATMENT: Group A: bomocriptine + FSH + HMG (10 patients); Group B: goserelin depot (Zoladex) + HMG (18 patients). RESULTS: A greater percentage of ovulations, pregnancies and a higher success rate were obtained in Group B. The percentage of hyperstimulation was similar in both groups; there was a higher percentage of abortion in Group A. Cycle duration and the number of phials of gonadotropin were greater in Group B. CONCLUSIONS: Treatment with bromocriptine + gonadotropin remains the simplest; the treatment protocol based on geserelin depot + gonadotropin proved to be more efficacious.
RCT Entities:
OBJECTIVE: To evaluate the efficacy and tolerability of treatment with goserelin + HMG vs bromocriptine + FSH + HMG in the induction of ovulation in patients with ovarian polycystosis. EXPERIMENTAL DESIGN: A randomized prospective study. PATIENTS: Sterile women with ovarian polycystosis of the first type not responding to clomiphene citrate. TREATMENT: Group A: bomocriptine + FSH + HMG (10 patients); Group B: goserelin depot (Zoladex) + HMG (18 patients). RESULTS: A greater percentage of ovulations, pregnancies and a higher success rate were obtained in Group B. The percentage of hyperstimulation was similar in both groups; there was a higher percentage of abortion in Group A. Cycle duration and the number of phials of gonadotropin were greater in Group B. CONCLUSIONS: Treatment with bromocriptine + gonadotropin remains the simplest; the treatment protocol based on geserelin depot + gonadotropin proved to be more efficacious.