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Literature DB >> 7630250

Association between clozapine response and allelic variation in 5-HT2A receptor gene.

M Arranz¹, D Collier, M Sodhi, D Ball, G Roberts, J Price, P Sham, R Kerwin.

Abstract

We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.

Entities: Chemical Disease Gene Mutation Species

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Year: 1995 PMID： 7630250 DOI： 10.1016/s0140-6736(95)92168-0

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

45 in total

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Association between clozapine response and allelic variation in 5-HT2A receptor gene.

1. Failure to respond to treatment with typical antipsychotics is not associated with CYP2D6 ultrarapid hydroxylation.

Review 2. Genetic variations in human G protein-coupled receptors: implications for drug therapy.

Review 3. Receptor pharmacogenetics: relevance to CNS syndromes.

Review 4. Gene-environment interplay in schizopsychotic disorders.

Review 5. Clinical staging in the pathophysiology of psychotic and affective disorders: facilitation of prognosis and treatment.

Review 6. Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

Review 7. Predictors and markers of clozapine response.

Review 8. Genetics and psychopharmacology: prospects for individualized treatment.

9. Association of the 5-HT2A receptor gene polymorphism 102T/C with ischemic stroke.

Review 10. G protein-coupled receptors in major psychiatric disorders.