Increased mortality rate from coronary artery disease following operation for coarctation of the aorta at a late age.

Sixty-six patients past 35 years of age at operation for coarctation of the aorta had significantly higher hospital (five of 66, 7.5 percent) and late cardiovascular (10 of 61, 16.4 percent) mortality rates than 137 patients aged 15 to 34 years (mean, 21.9 years). Three of the five hospital deaths, as well as four of the 10 late deaths, in the group greater than 35 years of age were due to myocardial infarction. Thus the total coronary mortality rate was 10.6 percent (seven of 66 patients), with all deaths occurring in men. It appears that coronary artery disease (CAD) is a significant complication in male patients who undergo operation for coarctation of the aorta at a late age.