Literature DB >> 7629657

Liposomally encapsulated diclofenac for sonophoresis induced systemic delivery.

S P Vyas1, R Singh, R K Asati.   

Abstract

Liposomes containing diclofenac, an anti-inflammatory agent were incorporated into an ointment base for topical application. The drug loaded liposomes were characterized for various physico-chemical attributes and drug efflux profile in in vitro. The systemic availability of drug from liposomes following topical application was evaluated in rats. The effect of sonophoresis on the drug release profile in vitro and systemic availability in vivo was established. The application of liposomal diclofenac resulted in localization of the drug at the site of application with slow systemic availability; however, with the application of ultrasound pulsed drug systemic levels could be achieved.

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Year:  1995        PMID： 7629657     DOI： 10.3109/02652049509015285

Source DB:  PubMed          Journal:  J Microencapsul        ISSN： 0265-2048            Impact factor:   3.142


  10 in total

Review 1.  Ultrasonic drug delivery--a general review.

Authors:  William G Pitt; Ghaleb A Husseini; Bryant J Staples
Journal:  Expert Opin Drug Deliv       Date:  2004-11       Impact factor: 6.648

2.  Diclofenac metabolic profile following in vitro percutaneous absorption through viable human skin.

Authors:  H Tanojo; R C Wester; J Z Shainhouse; H I Maibach
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1999 Oct-Dec       Impact factor: 2.441

3.  In vivo bioavailability and metabolism of topical diclofenac lotion in human volunteers.

Authors:  X Hui; P G Hewitt; N Poblete; H I Maibach; J Z Shainhouse; R C Wester
Journal:  Pharm Res       Date:  1998-10       Impact factor: 4.200

4.  Hydroxyzine from topical phospholipid liposomal formulations: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model.

Authors:  Abeer A W Elzainy; Xiaochen Gu; F Estelle R Simons; Keith J Simons
Journal:  AAPS PharmSci       Date:  2003-11-05

5.  In vitro cutaneous disposition of a topical diclofenac lotion in human skin: effect of a multi-dose regimen.

Authors:  P G Hewitt; N Poblete; R C Wester; H I Maibach; J Z Shainhouse
Journal:  Pharm Res       Date:  1998-07       Impact factor: 4.200

Review 6.  The use of ultrasound and micelles in cancer treatment.

Authors:  Ghaleb A Husseini; William G Pitt
Journal:  J Nanosci Nanotechnol       Date:  2008-05

Review 7.  Physical energy for drug delivery; poration, concentration and activation.

Authors:  Shanmugamurthy Lakshmanan; Gaurav K Gupta; Pinar Avci; Rakkiyappan Chandran; Magesh Sadasivam; Ana Elisa Serafim Jorge; Michael R Hamblin
Journal:  Adv Drug Deliv Rev       Date:  2013-06-07       Impact factor: 15.470

Review 8.  Application of liposomes in treatment of rheumatoid arthritis: quo vadis.

Authors:  Bhupinder Kapoor; Sachin Kumar Singh; Monica Gulati; Reena Gupta; Yogyata Vaidya
Journal:  ScientificWorldJournal       Date:  2014-02-04

9.  Mechanistic study of decreased skin penetration using a combination of sonophoresis with sodium fluorescein-loaded PEGylated liposomes with d-limonene.

Authors:  Worranan Rangsimawong; Praneet Opanasopit; Theerasak Rojanarata; Tanasait Ngawhirunpat
Journal:  Int J Nanomedicine       Date:  2015-12-15

Review 10.  Liposomal Nanosystems in Rheumatoid Arthritis.

Authors:  Margarida Ferreira-Silva; Catarina Faria-Silva; Pedro Viana Baptista; Eduarda Fernandes; Alexandra Ramos Fernandes; Maria Luísa Corvo
Journal:  Pharmaceutics       Date:  2021-03-27       Impact factor: 6.321
  10 in total

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