| Literature DB >> 7628610 |
N K Gopaul1, E E Anggård, A I Mallet, D J Betteridge, S P Wolff, J Nourooz-Zadeh.
Abstract
This study reports plasma levels of a specific nonenzymatic peroxidation product of arachidonic acid, esterified 8-epi-PGF2 alpha, from healthy- and NIDDM individuals as an index of oxidative stress in vivo. Plasma 8-epi-PGF2 alpha was isolated by solid-phase extraction on a C18 followed by an NH2 cartridge and analyzed by GC-MS/NICI as PFB-ester/TMS-ether derivative. We found that the average concentration of esterified 8-epi-PGF2 alpha among NIDDM subjects (0.93 +/- 0.07 nM, n = 39) was higher (P < 0.0001, Mann-Whitney test) than in healthy individuals (0.28 +/- 0.04 nM, n = 15). These data indicate that NIDDM is associated with increased plasma lipid peroxidation.Entities:
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Year: 1995 PMID： 7628610 DOI： 10.1016/0014-5793(95)00649-t
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124