J S Saini1, B Khandalavla. 1. Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract
OBJECTIVE: To assess corneal epithelial fragility in non-insulin-dependent diabetes mellitus (NIDDM) and its association with retinopathy. DESIGN: Survey. SETTING: University-affiliated hospital in Chandigarh, India. SUBJECTS: Seventy patients with NIDDM selected at random and 35 age-matched healthy control subjects recruited from hospital staff and their relatives. MAIN OUTCOME MEASURE: Corneal epithelial fragility, as measured with an esthesiometer. RESULTS: Mean corneal epithelial fragility values were significantly higher for the diabetic subjects without retinopathy than for the control subjects (p < 0.05). The mean epithelial fragility values for the eyes with diabetic proliferative retinopathy and those with nonproliferative retinopathy were significantly higher (by 84% and 41% respectively) than the mean value for the diabetic subjects without retinopathy (p < 0.05). There was no significant difference in mean epithelial fragility values between the proliferative and nonproliferative retinopathy groups. CONCLUSIONS: Eyes with diabetic retinopathy demonstrate increased corneal epithelial fragility.
OBJECTIVE: To assess corneal epithelial fragility in non-insulin-dependent diabetes mellitus (NIDDM) and its association with retinopathy. DESIGN: Survey. SETTING: University-affiliated hospital in Chandigarh, India. SUBJECTS: Seventy patients with NIDDM selected at random and 35 age-matched healthy control subjects recruited from hospital staff and their relatives. MAIN OUTCOME MEASURE: Corneal epithelial fragility, as measured with an esthesiometer. RESULTS: Mean corneal epithelial fragility values were significantly higher for the diabetic subjects without retinopathy than for the control subjects (p < 0.05). The mean epithelial fragility values for the eyes with diabetic proliferative retinopathy and those with nonproliferative retinopathy were significantly higher (by 84% and 41% respectively) than the mean value for the diabetic subjects without retinopathy (p < 0.05). There was no significant difference in mean epithelial fragility values between the proliferative and nonproliferative retinopathy groups. CONCLUSIONS: Eyes with diabetic retinopathy demonstrate increased corneal epithelial fragility.
Authors: M Saghizadeh; D J Brown; R Castellon; M Chwa; G H Huang; J Y Ljubimova; S Rosenberg; K S Spirin; R B Stolitenko; W Adachi; S Kinoshita; G Murphy; L J Windsor; M C Kenney; A V Ljubimov Journal: Am J Pathol Date: 2001-02 Impact factor: 4.307
Authors: Andrea Kabosova; Andrei A Kramerov; Annette M Aoki; Gillian Murphy; James D Zieske; Alexander V Ljubimov Journal: Exp Eye Res Date: 2003-08 Impact factor: 3.467