Literature DB >> 7627801

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?

D A Hume1, P Favot.   

Abstract

The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype.

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Year:  1995        PMID： 7627801     DOI： 10.1089/jir.1995.15.279

Source DB:  PubMed          Journal:  J Interferon Cytokine Res        ISSN： 1079-9907            Impact factor:   2.607


  3 in total

1.  Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects.

Authors:  Stephen E Harris; Mary MacDougall; Diane Horn; Kathleen Woodruff; Stephanie N Zimmer; Vivienne I Rebel; Roberto Fajardo; Jian Q Feng; Jelica Gluhak-Heinrich; Marie A Harris; Sherry Abboud Werner
Journal:  Bone       Date:  2011-09-20       Impact factor: 4.398

2.  The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification.

Authors:  Liesbeth Van Wesenbeeck; Paul R Odgren; Carole A MacKay; Marina D'Angelo; Fayez F Safadi; Steven N Popoff; Wim Van Hul; Sandy C Marks
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-11       Impact factor: 11.205

3.  Langerhans cells arise from monocytes in vivo.

Authors:  Florent Ginhoux; Frank Tacke; Veronique Angeli; Milena Bogunovic; Martine Loubeau; Xu-Ming Dai; E Richard Stanley; Gwendalyn J Randolph; Miriam Merad
Journal:  Nat Immunol       Date:  2006-01-29       Impact factor: 25.606
  3 in total

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