Literature DB >> 7627631

Ribozymes: biology, biochemistry, and implications for clinical medicine.

M Kiehntopf1, E L Esquivel, M A Brach, F Herrmann.   

Abstract

Ribozymes are a class of ribonucleic acid (RNA) molecules that possess enzymatic properties. Upon binding to complementary nucleic acid strands, catalytic degradation takes place via a cleavage reaction. In effect, inactivation of susceptible substrate RNA molecules takes place at a catalytic rate and with a high degree of substrate specificity. This article reviews the biology and biochemistry of this class of molecules and its potential applications in clinical medicine.

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Year:  1995        PMID： 7627631     DOI： 10.1007/bf00270579

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  55 in total

1.  A ribozyme with DNA in the hybridising arms displays enhanced cleavage ability.

Authors:  P Hendry; M J McCall; F S Santiago; P A Jennings
Journal:  Nucleic Acids Res       Date:  1992-11-11       Impact factor: 16.971

2.  Delta virus as a vector for the delivery of biologically-active RNAs: possibly a ribozyme specific for chronic hepatitis B virus infection.

Authors:  S Y Hsieh; J Taylor
Journal:  Adv Exp Med Biol       Date:  1992       Impact factor: 2.622

Review 3.  Ribozymes as anti-HIV-1 therapeutic agents: principles, applications, and problems.

Authors:  J J Rossi; D Elkins; J A Zaia; S Sullivan
Journal:  AIDS Res Hum Retroviruses       Date:  1992-02       Impact factor: 2.205

Review 4.  Progress toward human gene therapy.

Authors:  T Friedmann
Journal:  Science       Date:  1989-06-16       Impact factor: 47.728

5.  Structural and ionic requirements for self-cleavage of virusoid RNAs and trans self-cleavage of viroid RNA.

Authors:  A C Forster; A C Jeffries; C C Sheldon; R H Symons
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1987

6.  RNA catalytic properties of the minimum (-)sTRSV sequence.

Authors:  A Hampel; R Tritz
Journal:  Biochemistry       Date:  1989-06-13       Impact factor: 3.162

7.  The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme.

Authors:  C Guerrier-Takada; K Gardiner; T Marsh; N Pace; S Altman
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

8.  Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme.

Authors:  M Kashani-Sabet; T Funato; V A Florenes; O Fodstad; K J Scanlon
Journal:  Cancer Res       Date:  1994-02-15       Impact factor: 12.701

9.  Versatile adeno-associated virus 2-based vectors for constructing recombinant virions.

Authors:  P Nahreini; M J Woody; S Z Zhou; A Srivastava
Journal:  Gene       Date:  1993-02-28       Impact factor: 3.688

10.  Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1.

Authors:  E L Bertrand; J J Rossi
Journal:  EMBO J       Date:  1994-06-15       Impact factor: 11.598
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  3 in total

1.  Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.

Authors:  T Kuwabara; M Warashina; T Tanabe; K Tani; S Asano; K Taira
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

2.  Sense, antisense, nonsense: where's the right way?

Authors:  G Bricca
Journal:  J Mol Med (Berl)       Date:  1995-08       Impact factor: 4.599

3.  Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat.

Authors:  Amalia Sapag; Thergiory Irrazábal; Lorena Lobos-González; Carlos R Muñoz-Brauning; María Elena Quintanilla; Lutske Tampier
Journal:  Mol Ther Nucleic Acids       Date:  2016-07-12       Impact factor: 10.183
  3 in total

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