Literature DB >> 7626131

Assignment of disulphide bonds in the X protein (HBx) of hepatitis B virus.

A Gupta1, T K Mal, N Jayasuryan, V S Chauhan.   

Abstract

We have established the disulphide arrangement of cysteines in E. coli expressed HBx by chromatographic analysis of enzymatically cleaved protein and sequence analysis of cysteine containing fragments. Eight of the nine cysteines are disulphide linked in an interesting pattern. Each cysteine is linked to the fourth cysteine in a sequential manner and the last cysteine is free; the disulphide linkages are between Cys7 and Cys78, Cys17 and Cys115, Cys61 and Cys137, Cys69 and Cys143 while Cys148 is free.

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Year:  1995        PMID： 7626131     DOI： 10.1006/bbrc.1995.2057

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Aggregate formation of hepatitis B virus X protein affects cell cycle and apoptosis.

Authors:  Chang-Zheng Song; Zeng-Liang Bai; Chang-Cheng Song; Qing-Wei Wang
Journal:  World J Gastroenterol       Date:  2003-07       Impact factor: 5.742

2.  Structural characterization of an intrinsically unfolded mini-HBX protein from hepatitis B virus.

Authors:  Si-Hyung Lee; Eun-Ji Cha; Ji-Eun Lim; Soon-Hwan Kwon; Do-Hyoung Kim; Hyeseong Cho; Kyou-Hoon Han
Journal:  Mol Cells       Date:  2012-07-20       Impact factor: 5.034

3.  Immunohistochemical assessment and prognostic value of hepatitis B virus X protein in chronic hepatitis and primary hepatocellular carcinomas using anti-HBxAg monoclonal antibody.

Authors:  J Pál; C Somogyi; A Szmolenszky A; G Szekeres; J Sípos; G Hegedüs; I Martzinovits; J Molnár; P Németh
Journal:  Pathol Oncol Res       Date:  2001       Impact factor: 3.201

4.  A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

Authors:  V Kumar; N Jayasuryan; R Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

5.  Non-chromatographic Method for the Hepatitis B Virus X Protein Using Elastin-Like Polypeptide Fusion Protein.

Authors:  Soon-Hwan Kwon; Hyeseong Cho
Journal:  Osong Public Health Res Perspect       Date:  2012-06

6.  Prognostic significance of catalase expression and its regulatory effects on hepatitis B virus X protein (HBx) in HBV-related advanced hepatocellular carcinomas.

Authors:  Mi-Young Cho; Jae Youn Cheong; Wonchung Lim; Sujin Jo; Youngsoo Lee; Hee-Jung Wang; Kyou-Hoon Han; Hyeseong Cho
Journal:  Oncotarget       Date:  2014-12-15

Review 7.  Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system.

Authors:  Marissa M Minor; Betty L Slagle
Journal:  Viruses       Date:  2014-11-24       Impact factor: 5.048

8.  High-level expression and large-scale preparation of soluble HBx antigen from Escherichia coli.

Authors:  Dong Liu; Liyun Zou; Wanling Li; Li Wang; Yuzhang Wu
Journal:  Biotechnol Appl Biochem       Date:  2009-09-24       Impact factor: 2.431
  8 in total

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