Literature DB >> 7626059

Metabolism of highly persistent PCB congener, 2,4,5,2',4',5'-hexachlorobiphenyl, by human CYP2B6.

N Ariyoshi1, K Oguri, N Koga, H Yoshimura, Y Funae.   

Abstract

Metabolism of 2,4,5,2',4',5'-hexachlorobiphenyl was studied with cDNA-expressed human P450 2B isoform, CYP2B6. 3-Hydroxy-2,4,5,2',4',5'-hexachlorobiphenyl was identified as a major metabolite, and the formation activity was compared with that of dog CYP2B11 and guinea pig P450GP-1. The activity of 3-hydroxylation was comparable with that of P450GP-1, but one-tenth of CYP2B11. These results indicate that P450 2B in humans as well as other animal species can metabolize 2,4,5,2',4',5'-hexachlorobiphenyl, and the reason why this PCB congener remained most abundantly in human bodies is discussed.

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Year:  1995        PMID： 7626059     DOI： 10.1006/bbrc.1995.1991

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Monitoring OH-PCBs in PCB transport worker's urine as a non-invasive exposure assessment tool.

Authors:  Yuki Haga; Motoharu Suzuki; Chisato Matsumura; Toshihiro Okuno; Masahiro Tsurukawa; Kazuo Fujimori; Narayanan Kannan; Roland Weber; Takeshi Nakano
Journal:  Environ Sci Pollut Res Int       Date:  2018-04-14       Impact factor: 4.223

2.  Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan.

Authors:  Akio Koizumi; Kouji H Harada; Bita Eslami; Yoshinori Fujimine; Noriyuki Hachiya; Iwao Hirosawa; Kayoko Inoue; Sumiko Inoue; Shigeki Koda; Yukinori Kusaka; Katsuyuki Murata; Kazuyuki Omae; Norimitsu Saito; Shinichiro Shimbo; Katsunobu Takenaka; Tatsuya Takeshita; Hidemi Todoriki; Yasuhiko Wada; Takao Watanabe; Masayuki Ikeda
Journal:  Environ Health Prev Med       Date:  2009-05-28       Impact factor: 3.674

3.  Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.

Authors:  Igor O Shmarakov; Yun Jee Lee; Hongfeng Jiang; William S Blaner
Journal:  Toxicol Appl Pharmacol       Date:  2019-08-23       Impact factor: 4.219

Review 4.  Toxicokinetics of chiral polychlorinated biphenyls across different species--a review.

Authors:  Izabela Kania-Korwel; Hans-Joachim Lehmler
Journal:  Environ Sci Pollut Res Int       Date:  2015-04-01       Impact factor: 4.223

5.  Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat.

Authors:  Marianna Stamou; Eric Uwimana; Brenna M Flannery; Izabela Kania-Korwel; Hans-Joachim Lehmler; Pamela J Lein
Journal:  Toxicology       Date:  2015-10-14       Impact factor: 4.221

6.  Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences.

Authors:  Marianna Stamou; Xianai Wu; Izabela Kania-Korwel; Hans-Joachim Lehmler; Pamela J Lein
Journal:  Drug Metab Dispos       Date:  2013-11-19       Impact factor: 3.922

7.  Seasonal influences on PCB retention and biotransformation in fish.

Authors:  Margaret O James; Kevin M Kleinow
Journal:  Environ Sci Pollut Res Int       Date:  2013-03-14       Impact factor: 4.223

8.  Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl.

Authors:  Tsutomu Shimada; Kensaku Kakimoto; Shigeo Takenaka; Nobuyuki Koga; Shotaro Uehara; Norie Murayama; Hiroshi Yamazaki; Donghak Kim; F Peter Guengerich; Masayuki Komori
Journal:  Drug Metab Dispos       Date:  2016-09-13       Impact factor: 3.922

9.  The role of african american ethnicity and metabolism in sentinel polychlorinated biphenyl congener serum levels.

Authors:  Joseph E McGraw; Donald P Waller
Journal:  Environ Toxicol Pharmacol       Date:  2009-01       Impact factor: 4.860

10.  Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites.

Authors:  Xianai Wu; Austin Kammerer; Hans-Joachim Lehmler
Journal:  Environ Sci Technol       Date:  2014-02-05       Impact factor: 9.028
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