Literature DB >> 7625809

Concentration-dependent synergy and antagonism between cefoperazone and imipenem against methicillin-resistant Staphylococcus aureus.

K H Rand1, P Brown.   

Abstract

By the agar dilution checkerboard method, striking synergy between cefoperazone and imipenem was observed with 32 strains of methicillin-resistant Staphylococcus aureus (fractional inhibitory concentration indices, < or = 0.03 to 0.34; mean, 0.12 +/- 0.08). By the double-disk diffusion method, the synergy was confirmed, but about 60% of strains showed antagonism manifest by truncation of the zone of inhibition around cefoperazone. The mechanism may involve auxiliary factors distinct from those essential for the expression of methicillin resistance.

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Year:  1995        PMID： 7625809      PMCID： PMC162704          DOI： 10.1128/AAC.39.5.1173

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  In vitro synergistic activity between meropenem and other beta-lactams against methicillin-resistant Staphylococcus aureus.

Authors:  Y Sumita; S Mitsuhashi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

2.  In-vitro activity of imipenem combined with beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus.

Authors:  K Matsuda; Y Asahi; M Sanada; S Nakagawa; N Tanaka; M Inoue
Journal:  J Antimicrob Chemother       Date:  1991-06       Impact factor: 5.790

3.  Conversion of a homogeneously methicillin-resistant strain of Staphylococcus aureus to heterogeneous resistance by Tn551-mediated insertional inactivation.

Authors:  J Kornblum; B J Hartman; R P Novick; A Tomasz
Journal:  Eur J Clin Microbiol       Date:  1986-12       Impact factor: 3.267

4.  Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method.

Authors:  H O Hallander; K Dornbusch; L Gezelius; K Jacobson; I Karlsson
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

5.  Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus.

Authors:  B J Hartman; A Tomasz
Journal:  J Bacteriol       Date:  1984-05       Impact factor: 3.490

Review 6.  Molecular aspects of methicillin resistance in Staphylococcus aureus.

Authors:  H de Lencastre; B L de Jonge; P R Matthews; A Tomasz
Journal:  J Antimicrob Chemother       Date:  1994-01       Impact factor: 5.790

7.  The effect of combinations of cefotiam and other antibiotics on methicillin-resistant Staphylococcus aureus in vitro.

Authors:  A Sugiura; K Jono; T Kono; E Higashide
Journal:  J Antimicrob Chemother       Date:  1991-11       Impact factor: 5.790

8.  Effects of temperature, NaCl, and methicillin on penicillin-binding proteins, growth, peptidoglycan synthesis, and autolysis in methicillin-resistant Staphylococcus aureus.

Authors:  M V Madiraju; D P Brunner; B J Wilkinson
Journal:  Antimicrob Agents Chemother       Date:  1987-11       Impact factor: 5.191

9.  Effect of NaCl and nafcillin on penicillin-binding protein 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus.

Authors:  H F Chambers; C J Hackbarth
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191

10.  Mapping and characterization of multiple chromosomal factors involved in methicillin resistance in Staphylococcus aureus.

Authors:  B Berger-Bächi; A Strässle; J E Gustafson; F H Kayser
Journal:  Antimicrob Agents Chemother       Date:  1992-07       Impact factor: 5.191
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  3 in total

1.  Optimal drug synergy in antimicrobial treatments.

Authors:  Joseph Peter Torella; Remy Chait; Roy Kishony
Journal:  PLoS Comput Biol       Date:  2010-06-03       Impact factor: 4.475

2.  Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution.

Authors:  Shaon Chakrabarti; Franziska Michor
Journal:  Cancer Res       Date:  2017-05-31       Impact factor: 12.701

3.  Synergistic effect of chlorogenic acid and levofloxacin against Klebsiella pneumonia infection in vitro and in vivo.

Authors:  Shirui Tan; Jing Gao; Qingrong Li; Tieying Guo; Xiangshu Dong; Xuehui Bai; Jinghui Yang; Shumei Hao; Feifei He
Journal:  Sci Rep       Date:  2020-11-17       Impact factor: 4.379
  3 in total

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