OBJECTIVE: The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response. METHOD: During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol. RESULTS: No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected. CONCLUSIONS: Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.
RCT Entities:
OBJECTIVE: The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response. METHOD: During a 2-week, double-blind, randomized fixed-dose study, 24 psychoticpatients were given 4, 10, or 40 mg/day of haloperidol. RESULTS: No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected. CONCLUSIONS: Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.
Authors: Waleed M Sweileh; Jihad Bani Odeh; Naser Y Shraim; Sa'ed H Zyoud; Ansam F Sawalha; Samah W Al-Jabi Journal: Saudi Pharm J Date: 2013-04-06 Impact factor: 4.330