OBJECTIVE: This study was undertaken to obtain detailed measurements of the volume of the brain, using magnetic resonance imaging (MRI), in a carefully selected group of autistic subjects and comparison subjects. METHOD: Twenty-two male autistic subjects and 20 male volunteer comparison subjects were examined with detailed (1.5-mm slices) MRI throughout the entire brain. Total brain, total brain tissue, and total lateral ventricle volumes were measured by using manual tracing and automated techniques. RESULTS: After height and performance IQ were controlled, autistic subjects had significantly greater total brain, total tissue, and total lateral ventricle volumes than comparison subjects. CONCLUSIONS: These findings suggest that male autistic subjects have enlarged brains and that enlargement is a result of both greater brain tissue volume and greater lateral ventricle volume.
OBJECTIVE: This study was undertaken to obtain detailed measurements of the volume of the brain, using magnetic resonance imaging (MRI), in a carefully selected group of autistic subjects and comparison subjects. METHOD: Twenty-two male autistic subjects and 20 male volunteer comparison subjects were examined with detailed (1.5-mm slices) MRI throughout the entire brain. Total brain, total brain tissue, and total lateral ventricle volumes were measured by using manual tracing and automated techniques. RESULTS: After height and performance IQ were controlled, autistic subjects had significantly greater total brain, total tissue, and total lateral ventricle volumes than comparison subjects. CONCLUSIONS: These findings suggest that male autistic subjects have enlarged brains and that enlargement is a result of both greater brain tissue volume and greater lateral ventricle volume.
Authors: Maria C N Marchetto; Cassiano Carromeu; Allan Acab; Diana Yu; Gene W Yeo; Yangling Mu; Gong Chen; Fred H Gage; Alysson R Muotri Journal: Cell Date: 2010-11-12 Impact factor: 41.582
Authors: J L Allen; G Oberdorster; K Morris-Schaffer; C Wong; C Klocke; M Sobolewski; K Conrad; M Mayer-Proschel; D A Cory-Slechta Journal: Neurotoxicology Date: 2015-12-22 Impact factor: 4.294
Authors: Antonio Y Hardan; Sri Muddasani; Madhuri Vemulapalli; Matcheri S Keshavan; Nancy J Minshew Journal: Am J Psychiatry Date: 2006-07 Impact factor: 18.112
Authors: Inbal Boger-Megiddo; Dennis W W Shaw; Seth D Friedman; Bobbi F Sparks; Alan A Artru; Jay N Giedd; Geraldine Dawson; Stephen R Dager Journal: J Autism Dev Disord Date: 2006-08
Authors: Manuel F Casanova; Ayman El-Baz; Meghan Mott; Glenn Mannheim; Hossam Hassan; Rachid Fahmi; Jay Giedd; Judith M Rumsey; Andrew E Switala; Aly Farag Journal: J Autism Dev Disord Date: 2009-01-16