Literature DB >> 7624960

A human model of xenogeneic graft-versus-host disease in SCID mice engrafted with human peripheral blood lymphocytes.

J S Sandhu1, R Gorczynski, B Shpitz, S Gallinger, H P Nguyen, N Hozumi.   

Abstract

Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with human peripheral blood lymphocytes (Hu-PBLs). The engraftment efficiency is extremely high, such that 100% of Hu-PBL-SCID mice die of XGVHD within 4 weeks after engraftment with Hu-PBLs (3-5 x 10(7) cells). A series of experiments was performed to investigate the mechanisms involved in the severe XGVHD. The results suggest that XGVHD was induced by human CD4+ T cells, antixenogeneic (antimouse) antibodies, and lymphokines. The SCID mouse model will be extremely valuable for the evaluation and development of immunosuppressive agents and transplantation protocols for human XGVHD.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7624960

Source DB:  PubMed          Journal:  Transplantation        ISSN： 0041-1337            Impact factor:   4.939


  13 in total

Review 1.  Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance.

Authors:  Young-June Kim; Hal E Broxmeyer
Journal:  Crit Rev Oncol Hematol       Date:  2010-08-19       Impact factor: 6.312

2.  Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγ(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.

Authors:  L Covassin; J Laning; R Abdi; D L Langevin; N E Phillips; L D Shultz; M A Brehm
Journal:  Clin Exp Immunol       Date:  2011-11       Impact factor: 4.330

3.  Update of humanized animal disease models in studying Graft-versus-host disease.

Authors:  Feng Huang; Feng Lin Cao; Song Guo Zheng
Journal:  Hum Vaccin Immunother       Date:  2018-09-05       Impact factor: 3.452

4.  An Animal Model That Mimics Human Herpesvirus 6B Pathogenesis.

Authors:  Bochao Wang; Yasuyuki Saito; Mitsuhiro Nishimura; Zhenxiao Ren; Lidya Handayani Tjan; Alaa Refaat; Rie Iida-Norita; Ryuko Tsukamoto; Masato Komatsu; Tomoo Itoh; Takashi Matozaki; Yasuko Mori
Journal:  J Virol       Date:  2020-02-28       Impact factor: 5.103

5.  Islet xenograft destruction in the hu-PBL-severe combined immunodeficient (SCID) mouse necessitates anti-CD3 preactivation of human immune cells.

Authors:  C Gysemans; M Waer; J Laureys; J Depovere; D Pipeleers; R Bouillon; C Mathieu
Journal:  Clin Exp Immunol       Date:  2000-09       Impact factor: 4.330

6.  Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model.

Authors:  Takashi Onoe; Hannes Kalscheuer; Nichole Danzl; Meredith Chittenden; Guiling Zhao; Yong-Guang Yang; Megan Sykes
Journal:  J Immunol       Date:  2011-08-29       Impact factor: 5.422

7.  IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease.

Authors:  Sameek Roychowdhury; Bradley W Blaser; Aharon G Freud; Kerry Katz; Darshna Bhatt; Amy K Ferketich; Valerie Bergdall; Donna Kusewitt; Robert A Baiocchi; Michael A Caligiuri
Journal:  Blood       Date:  2005-06-23       Impact factor: 22.113

Review 8.  Human allograft rejection in humanized mice: a historical perspective.

Authors:  Michael A Brehm; Leonard D Shultz
Journal:  Cell Mol Immunol       Date:  2012-02-13       Impact factor: 11.530

9.  Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice.

Authors:  Bruno Nervi; Michael P Rettig; Julie K Ritchey; Hanlin L Wang; Gerhard Bauer; Jon Walker; Mark L Bonyhadi; Ronald J Berenson; Julie L Prior; David Piwnica-Worms; Jan A Nolta; John F DiPersio
Journal:  Exp Hematol       Date:  2007-08-30       Impact factor: 3.084

10.  Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation.

Authors:  T A Seldon; R Pryor; A Palkova; M L Jones; N D Verma; M Findova; K Braet; Y Sheng; Y Fan; E Y Zhou; J D Marks; T Munro; S M Mahler; R T Barnard; P D Fromm; P A Silveira; Z Elgundi; X Ju; G J Clark; K F Bradstock; D J Munster; D N J Hart
Journal:  Leukemia       Date:  2015-08-19       Impact factor: 11.528
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.