Literature DB >> 7624287

In vivo metabolism of aminopyrine by the larvae of the helminth Heligmosomoides polygyrus.

D Kerboeuf1, D Soubieux, R Guilluy, J L Brazier, J L Rivière.   

Abstract

The in vivo N-dealkylation of [13C-2]-labeled aminopyrine by the L1-L2 larvae of Heligmosomoides polygyrus was demonstrated by the use of a sensitive gas chromatography-mass spectrometry method. This is the first evidence for the possible existence of a cytochrome P-450-dependent activity in helminths.

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Year:  1995        PMID： 7624287     DOI： 10.1007/bf00931534

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  14 in total

Review 1.  Prediction of xenobiotic metabolism by non-invasive methods.

Authors:  S Loft; H E Poulsen
Journal:  Pharmacol Toxicol       Date:  1990-08

2.  A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes.

Authors:  J Hubert; D Kerboeuf
Journal:  Vet Rec       Date:  1992-05-16       Impact factor: 2.695

3.  The possible absence of cytochrome P-450 linked xenobiotic metabolism in helminths.

Authors:  W Y Precious; J Barrett
Journal:  Biochim Biophys Acta       Date:  1989-08-18

4.  The 14CO2 breath test: facilities and limitations of a rapid and noninvasive method for in vivo evaluation of modified hepatic cytochrome P-450--a critique.

Authors:  M Brüch; L Kling; W Legrum; E Maser
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

5.  On-line measurements of 13C enrichments in rat breath. Non-invasive method for in vivo study of drug enzymatic induction.

Authors:  R Guilluy; F Billion-Rey; J L Brazier
Journal:  J Chromatogr       Date:  1991-01-02

6.  Xenobiotic metabolism in helminths.

Authors:  W Y Precious; J Barrett
Journal:  Parasitol Today       Date:  1989-05

7.  Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.

Authors:  A D Rodrigues; D F Lewis; C Ioannides; D V Parke
Journal:  Xenobiotica       Date:  1987-11       Impact factor: 1.908

8.  Colorimetric assay for the detection of benzimidazole resistance in trichostrongyles.

Authors:  I A Sutherland; D L Lee; D Lewis
Journal:  Res Vet Sci       Date:  1989-05       Impact factor: 2.534

Review 9.  Evolution of the cytochrome P450 genes.

Authors:  D W Nebert; D R Nelson; R Feyereisen
Journal:  Xenobiotica       Date:  1989-10       Impact factor: 1.908

Review 10.  Cytochrome P450 monooxygenases in crustaceans.

Authors:  M O James
Journal:  Xenobiotica       Date:  1989-10       Impact factor: 1.908
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  4 in total

1.  Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole.

Authors:  Catherine Devine; Gerard P Brennan; Carlos E Lanusse; Luis I Alvarez; Alan Trudgett; Elizabeth Hoey; Ian Fairweather
Journal:  Parasitol Res       Date:  2010-05-30       Impact factor: 2.289

2.  The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica.

Authors:  Mark W Robinson; Jill Lawson; Alan Trudgett; Elizabeth M Hoey; Ian Fairweather
Journal:  Parasitol Res       Date:  2003-12-03       Impact factor: 2.289

3.  Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae.

Authors:  Andrew C Kotze; Angela P Ruffell; Aaron B Ingham
Journal:  Antimicrob Agents Chemother       Date:  2014-10-06       Impact factor: 5.191

4.  Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes.

Authors:  Noemi Cowan; Charles Meier; Anna Neodo; Jennifer Keiser
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2017-03-24       Impact factor: 4.077
  4 in total

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