[The influence of hepatitis B vaccine dose on direct results of hepatitis B vaccination in children with nephrotic syndrome].

In the first phase of the study on the efficacy of vaccination against hepatitis B with a double dose of the vaccine in children with steroid-sensitive nephrotic syndrome (NS), the best results were obtained in the group of patients in remission of NS. The aim of the present study was to compare the efficacy of standard and double doses of the vaccine in patients in remission. After excluding HBV infection, recombinant hepatitis B vaccine was administered i.m. according to the 0, 1, 2 month protocol in a standard dose in group I and a double dose in group II. In both groups the seroprotection rate was similar (I group-96%, II group-93%), however the anti-HBs antibody level was significantly higher in group II during a 3 month observation period.

RCT Entities:   Population Interventions Outcomes