Literature DB >> 7623069

Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.

M Kameyama1, K Ishiwata, Y Tsurumi, J Itoh, K Sato, R Katakura, T Yoshimoto, J Hatazawa, M Ito, T Ido.   

Abstract

Positron emission tomography was used to investigate the metabolism of nucleic acids by 18F-fluoro-2'-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.

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Year:  1995        PMID： 7623069     DOI： 10.1007/bf01058459

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  40 in total

1.  Performance characteristics of a whole-body positron tomograph.

Authors:  T J Spinks; R Guzzardi; C R Bellina
Journal:  J Nucl Med       Date:  1988-11       Impact factor: 10.057

2.  Blood flow and oxygen utilisation in the contralateral cerebral cortex of patients with untreated intracranial tumours as studied by positron emission tomography, with observations on the effect of decompressive surgery.

Authors:  R P Beaney; D J Brooks; K L Leenders; D G Thomas; T Jones; K E Halnan
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-04       Impact factor: 10.154

3.  Stereotaxic biopsy and positron emission tomography correlation of cerebral gliomas.

Authors:  C Worthington; J L Tyler; J G Villemure
Journal:  Surg Neurol       Date:  1987-01

4.  Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.

Authors:  N J Patronas; G Di Chiro; R A Brooks; R L DeLaPaz; P L Kornblith; B H Smith; H V Rizzoli; R M Kessler; R G Manning; M Channing; A P Wolf; C M O'Connor
Journal:  Radiology       Date:  1982-09       Impact factor: 11.105

5.  Ten-year survival among patients with supratentorial astrocytomas grade III and IV.

Authors:  L G Salford; A Brun; S Nirfalk
Journal:  J Neurosurg       Date:  1988-10       Impact factor: 5.115

6.  In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas.

Authors:  C G Rhodes; R J Wise; J M Gibbs; R S Frackowiak; J Hatazawa; A J Palmer; D G Thomas; T Jones
Journal:  Ann Neurol       Date:  1983-12       Impact factor: 10.422

7.  ECAT: a new computerized tomographic imaging system for positron-emitting radiopharmaceuticals.

Authors:  M E Phelps; E J Hoffman; S C Huang; D E Kuhl
Journal:  J Nucl Med       Date:  1978-06       Impact factor: 10.057

8.  Multicentric glioma studied with positron emission tomography: a case report.

Authors:  K Sato; M Kameyama; K Ishiwata; T Kayama; T Yoshimoto; M Ito
Journal:  Surg Neurol       Date:  1994-07

9.  Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study.

Authors:  G Di Chiro; J Hatazawa; D A Katz; H V Rizzoli; D J De Michele
Journal:  Radiology       Date:  1987-08       Impact factor: 11.105

10.  Studies on regional cerebral haematocrit and blood flow in patients with cerebral tumours using positron emission tomography.

Authors:  D J Brooks; R P Beaney; A A Lammertsma; D R Turton; J Marshall; D G Thomas; T Jones
Journal:  Microvasc Res       Date:  1986-05       Impact factor: 3.514
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