Literature DB >> 7623049

Antineoplastic agents, 301. An investigation of the Amaryllidaceae genus Hymenocallis.

G R Pettit1, G R Pettit1, G Groszek, R A Backhaus, D L Doubek, R J Barr, A W Meerow.   

Abstract

Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection, were investigated as sources of pancratistatin [1] now undergoing preclinical development as an anticancer agent. Pancratistatin [1] was found to be a constituent of H. speciosa (Singapore), H. variegated (Singapore), H. pedalis (Seychelles), H. expansa (Bermuda), H. sonoranensis (Mexico), and P. maritimum (Israel). Only two species of Hymenocallis failed to yield one or more of the related cell-growth inhibitory isocarbostyrils such as narciclasine [3a], 7-deoxynarciclasine [3b], and 7-deoxy-trans-dihydronarciclasine [2].

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7623049     DOI： 10.1021/np50119a017

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

Review 1.  Chemistry, biology, and medicinal potential of narciclasine and its congeners.

Authors:  Alexander Kornienko; Antonio Evidente
Journal:  Chem Rev       Date:  2008-05-20       Impact factor: 60.622

2.  Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis.

Authors:  Cheri Lubahn; Jill A Schaller; Eric Shewmacker; Carlo Wood; Denise L Bellinger; Donna Byron; Noeleen Melody; George R Pettit; Dianne Lorton
Journal:  Rheumatol Int       Date:  2011-12-09       Impact factor: 2.631

3.  Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies.

Authors:  George R Pettit; Rui Tan; Guan-Hu Bao; Noeleen Melody; Dennis L Doubek; Song Gao; Jean-Charles Chapuis; Lee Williams
Journal:  J Nat Prod       Date:  2012-03-13       Impact factor: 4.050

4.  TOTAL SYNTHESES OF PANCRATISTATIN. A REVIEW.

Authors:  Madhuri Manpadi; Alexander Kornienko
Journal:  Org Prep Proced Int       Date:  2009-02-18       Impact factor: 1.628

Review 5.  Chemical and biological aspects of Narcissus alkaloids.

Authors:  Jaume Bastida; Rodolfo Lavilla; Francesc Viladomat
Journal:  Alkaloids Chem Biol       Date:  2006

6.  Synthesis of some members of the hydroxylated phenanthridone subclass of the Amaryllidaceae alkaloid family.

Authors:  Albert Padwa; Hongjun Zhang
Journal:  J Org Chem       Date:  2007-03-06       Impact factor: 4.354

7.  In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans.

Authors:  M Ouarzane-Amara; J F Franetich; D Mazier; G R Pettit; L Meijer; C Doerig; I Desportes-Livage
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

8.  Amaryllidaceae isocarbostyril alkaloids and their derivatives as promising antitumor agents.

Authors:  Laurent Ingrassia; Florence Lefranc; Véronique Mathieu; Francis Darro; Robert Kiss
Journal:  Transl Oncol       Date:  2008-03       Impact factor: 4.243

9.  The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds.

Authors:  Dinar S C Wahyuni; Frank van der Kooy; Peter G L Klinkhamer; Rob Verpoorte; Kirsten Leiss
Journal:  Molecules       Date:  2013-04-17       Impact factor: 4.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.