Literature DB >> 76229

Passive immunisation with serum and immunoglobulins against dental caries in rhesus monkeys.

T Lehner, M W Russell, S J Challacombe, C M Scully, J E Hawkes.   

Abstract

Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.

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Year:  1978        PMID： 76229     DOI： 10.1016/s0140-6736(78)90803-6

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  13 in total

1.  Bacterial and strain specificities in opsonization, phagocytosis and killing of Streptococcus mutans.

Authors:  C M Scully; T Lehner
Journal:  Clin Exp Immunol       Date:  1979-01       Impact factor: 4.330

2.  T-cell, adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II.

Authors:  C G Kelly; S Todryk; H L Kendal; G H Munro; T Lehner
Journal:  Infect Immun       Date:  1995-09       Impact factor: 3.441

Review 3.  Recent advances in the development of a Streptococcus mutans vaccine.

Authors:  J P Klein; M Scholler
Journal:  Eur J Epidemiol       Date:  1988-12       Impact factor: 8.082

4.  Oral immunization with Streptococcus mutants in rhesus monkeys and the development of immune response and dental caries.

Authors:  T Lehner; S J Challacombe; J Caldwell
Journal:  Immunology       Date:  1980-12       Impact factor: 7.397

5.  Comparative opsonic activity for Steptococcus mutans in oral fluids, and phagocytic activity of blood, crevicular, and salivary polymorphonuclear leucocytes in rhesus monkeys.

Authors:  C M Scully
Journal:  Immunology       Date:  1980-01       Impact factor: 7.397

Review 6.  Biology, immunology, and cariogenicity of Streptococcus mutans.

Authors:  S Hamada; H D Slade
Journal:  Microbiol Rev       Date:  1980-06

7.  Specificity of monoclonal antibodies in local passive immunization against Streptococcus mutans.

Authors:  J K Ma; M Hunjan; R Smith; T Lehner
Journal:  Clin Exp Immunol       Date:  1989-09       Impact factor: 4.330

8.  Local passive immunization by monoclonal antibodies against streptococcal antigen I/II in the prevention of dental caries.

Authors:  T Lehner; J Caldwell; R Smith
Journal:  Infect Immun       Date:  1985-12       Impact factor: 3.441

9.  Protection of gnotobiotic rats against dental caries by passive immunization with bovine milk antibodies to Streptococcus mutans.

Authors:  S M Michalek; R L Gregory; C C Harmon; J Katz; G J Richardson; T Hilton; S J Filler; J R McGhee
Journal:  Infect Immun       Date:  1987-10       Impact factor: 3.441

10.  Antibody responses of monkeys to oral and local immunization with Streptococcus mutans.

Authors:  J Walker
Journal:  Infect Immun       Date:  1981-01       Impact factor: 3.441
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