Literature DB >> 7622436

Pyripyropenes, Novel ACAT inhibitors produced by Aspergillus fumigatus. III. Structure elucidation of pyripyropenes E to L.

H Tomoda1, N Tabata, D J Yang, H Takayanagi, H Nishida, S Omura, T Kaneko.   

Abstract

Eight new pyripyropenes, E to L, were isolated from the culture broth of Aspergillus fumigatus FO-1289-2501 selected as a higher producer by NTG mutation. Structural elucidation indicated that all the pyripyropenes have the same pyridino-alpha-pyrone sesquiterpene core as pyripyropenes A to D. Among them, pyripyropene L showed the most potent inhibition against acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 value of 0.27 microM in rat liver microsomes.

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Year:  1995        PMID： 7622436     DOI： 10.7164/antibiotics.48.495

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69.

Authors:  Zhuang Ding; Lianqing Zhang; Juan Fu; Qian Che; Dehai Li; Qianqun Gu; Tianjiao Zhu
Journal:  J Antibiot (Tokyo)       Date:  2015-06-10       Impact factor: 2.649

2.  Study on Secondary Metabolites of Endophytic Fungus, Aspergillus fumigatus, from Crocus sativus L. Guided byUHPLC-HRMS/MS-Based Molecular Network.

Authors:  Yu Jiang; Jing Wu; Hirokazu Kawagishi; Chunxiao Jiang; Qi Zhou; Zheren Tong; Yingpeng Tong; Ping Wang
Journal:  Int J Anal Chem       Date:  2022-05-09       Impact factor: 1.698

Review 3.  Angiosuppressive properties of marine-derived compounds-a mini review.

Authors:  Patrick Y K Yue; H M Leung; Adela J Li; Tracy N C Chan; T S Lum; Y L Chung; Y H Sung; M H Wong; Kelvin S Y Leung; Eddy Y Zeng
Journal:  Environ Sci Pollut Res Int       Date:  2015-10-31       Impact factor: 4.223

4.  Characterization of two acetyltransferase genes in the pyripyropene biosynthetic gene cluster from Penicillium coprobium.

Authors:  Jie Hu; Ayako Furutani; Kentaro Yamamoto; Kazuhiko Oyama; Masaaki Mitomi; Hiroyuki Anzai
Journal:  Biotechnol Biotechnol Equip       Date:  2014-10-31       Impact factor: 1.632

5.  New isocoumarin derivatives and meroterpenoids from the marine sponge-associated fungus Aspergillus similanensis sp. nov. KUFA 0013.

Authors:  Chadaporn Prompanya; Tida Dethoup; Lucinda J Bessa; Madalena M M Pinto; Luís Gales; Paulo M Costa; Artur M S Silva; Anake Kijjoa
Journal:  Mar Drugs       Date:  2014-10-14       Impact factor: 5.118

6.  Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7.

Authors:  Yu Wang; Da-Hong Li; Zhan-Lin Li; Yan-Jun Sun; Hui-Ming Hua; Tao Liu; Jiao Bai
Journal:  Molecules       Date:  2015-12-28       Impact factor: 4.411

7.  Synthesis of pyripyropene derivatives and their pest-control efficacy.

Authors:  Kimihiko Goto; Ryo Horikoshi; Satoshi Nakamura; Masaaki Mitomi; Kazuhiko Oyama; Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Ōmura
Journal:  J Pestic Sci       Date:  2019-07-25       Impact factor: 2.529

8.  Afidopyropen, a novel insecticide originating from microbial secondary extracts.

Authors:  Ryo Horikoshi; Kimihiko Goto; Masaaki Mitomi; Kazuhiko Oyama; Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Ōmura
Journal:  Sci Rep       Date:  2022-02-18       Impact factor: 4.379

9.  Identification of Antibacterial Metabolites from Endophytic Fungus Aspergillus fumigatus, Isolated from Albizia lucidior Leaves (Fabaceae), Utilizing Metabolomic and Molecular Docking Techniques.

Authors:  Mai E Hussein; Osama G Mohamed; Ahlam M El-Fishawy; Hesham I El-Askary; Amira S El-Senousy; Ahmed A El-Beih; Eman S Nossier; Ahmed M Naglah; Abdulrahman A Almehizia; Ashootosh Tripathi; Ahmed A Hamed
Journal:  Molecules       Date:  2022-02-08       Impact factor: 4.411

10.  Studies on the Chemical Diversities of Secondary Metabolites Produced by Neosartorya fischeri via the OSMAC Method.

Authors:  You-Min Ying; Lu Huang; Ting Tian; Cui-Yu Li; Shi-Lei Wang; Lie-Feng Ma; Wei-Guang Shan; Jian-Wei Wang; Zha-Jun Zhan
Journal:  Molecules       Date:  2018-10-25       Impact factor: 4.411
  10 in total

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