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Literature DB >> 7622250

Hemolytic activity of the Pasteurella haemolytica leukotoxin.

G L Murphy¹, L C Whitworth, K D Clinkenbeard, P A Clinkenbeard.

Abstract

A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demonstrated the typical beta-hemolytic phenotype on sheep and rabbit blood agar, whereas the mutant did not.

Entities: Chemical Disease Species

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Year: 1995 PMID： 7622250 PMCID： PMC173439 DOI： 10.1128/iai.63.8.3209-3212.1995

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant.

Authors: C A Strathdee; R Y Lo
Journal: J Bacteriol Date: 1989-02 Impact factor: 3.490

2. Transmembrane pore size and role of cell swelling in cytotoxicity caused by Pasteurella haemolytica leukotoxin.

Authors: K D Clinkenbeard; D A Mosier; A W Confer
Journal: Infect Immun Date: 1989-02 Impact factor: 3.441

3. Hemoglobin enhancement of experimental infection of mice with Pasteurella haemolytica.

Authors: M M Chengappa; G R Carter; T S Chang
Journal: Am J Vet Res Date: 1983-08 Impact factor: 1.156

4. Demonstration of age-dependent capsular material on Pasteurella haemolytica serotype 1.

Authors: R E Corstvet; M J Gentry; P R Newman; J A Rummage; A W Confer
Journal: J Clin Microbiol Date: 1982-12 Impact factor: 5.948

5. Cytotoxin of Pasteurella haemolytica acting on bovine leukocytes.

Authors: P E Shewen; B N Wilkie
Journal: Infect Immun Date: 1982-01 Impact factor: 3.441

6. Nucleotide sequence of the leukotoxin genes of Pasteurella haemolytica A1.

Authors: R Y Lo; C A Strathdee; P E Shewen
Journal: Infect Immun Date: 1987-09 Impact factor: 3.441

7. DNA sequence of the Pasteurella haemolytica leukotoxin gene cluster.

Authors: S K Highlander; M Chidambaram; M J Engler; G M Weinstock
Journal: DNA Date: 1989 Jan-Feb

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Authors: M L Benson; R G Thomson; V E Valli
Journal: Can J Comp Med Date: 1978-07

9. Nonreciprocal complementation of the hlyC and lktC genes of the Escherichia coli hemolysin and Pasteurella haemolytica leukotoxin determinants.

Authors: C Forestier; R A Welch
Journal: Infect Immun Date: 1990-03 Impact factor: 3.441

10. Isolation of Pasteurella haemolytica leukotoxin mutants.

Authors: M Chidambaram; B Sharma; S F Petras; C P Reese; S Froshauer; G M Weinstock
Journal: Infect Immun Date: 1995-03 Impact factor: 3.441

23 in total

1. Mannheimia haemolytica leukotoxin induces apoptosis of bovine lymphoblastoid cells (BL-3) via a caspase-9-dependent mitochondrial pathway.

Authors: Dhammika N Atapattu; Charles J Czuprynski
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

2. Evidence for vertical inheritance and loss of the leukotoxin operon in genus Mannheimia.

Authors: Jesper Larsen; Anders G Pedersen; Henrik Christensen; Magne Bisgaard; Øystein Angen; Peter Ahrens; John E Olsen
Journal: J Mol Evol Date: 2007-04-13 Impact factor: 2.395

3. Inactivation of Pasteurella (Mannheimia) haemolytica leukotoxin causes partial attenuation of virulence in a calf challenge model.

Authors: S K Highlander; N D Fedorova; D M Dusek; R Panciera; L E Alvarez; C Rinehart
Journal: Infect Immun Date: 2000-07 Impact factor: 3.441

4. Generation of targeted nonpolar gene insertions and operon fusions in Pasteurella haemolytica and creation of a strain that produces and secretes inactive leukotoxin.

Authors: N D Fedorova; S K Highlander
Journal: Infect Immun Date: 1997-07 Impact factor: 3.441

5. Cytotoxic effects of Kingella kingae outer membrane vesicles on human cells.

Authors: R Maldonado; R Wei; S C Kachlany; M Kazi; N V Balashova
Journal: Microb Pathog Date: 2011-04-02 Impact factor: 3.738

6. Pasteurella haemolytica leukotoxin-induced increase in phospholipase A2 activity in bovine neutrophils.

Authors: Z Wang; C Clarke; K Clinkenbeard
Journal: Infect Immun Date: 1998-05 Impact factor: 3.441

7. Cloning and characterization of the gene encoding Pasteurella haemolytica FnrP, a regulator of the Escherichia coli silent hemolysin sheA.

Authors: G A Uhlich; P J McNamara; J J Iandolo; D A Mosier
Journal: J Bacteriol Date: 1999-06 Impact factor: 3.490

8. Proteomic analysis and immunogenicity of Mannheimia haemolytica vesicles.

Authors: Sahlu Ayalew; Anthony W Confer; Binu Shrestha; Amanda E Wilson; Marie Montelongo
Journal: Clin Vaccine Immunol Date: 2012-12-12

9. Correlation of Pasteurella haemolytica leukotoxin binding with susceptibility to intoxication of lymphoid cells from various species.

Authors: Y Sun; K D Clinkenbeard; L A Cudd; C R Clarke; P A Clinkenbeard
Journal: Infect Immun Date: 1999-12 Impact factor: 3.441

10. Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects.

Authors: Rohana P Dassanayake; Samuel K Maheswaran; Subramaniam Srikumaran
Journal: Infect Immun Date: 2007-08-13 Impact factor: 3.441