Literature DB >> 7622068

The human gene encoding the largest subunit of RNA polymerase II.

K Mita1, H Tsuji, M Morimyo, E Takahashi, M Nenoi, S Ichimura, M Yamauchi, E Hongo, A Hayashi.   

Abstract

The nucleotide sequence of a large portion of the human RNA polymerase II large subunit (RpII LS)-encoding gene and its whole gene structure were determined. The RpIILS gene consists of 29 exons. The sequence of the 5' flanking region is highly conserved as compared with that of the mouse RpIILS and contains several SP1-binding sites, a CCAAT sequence and a sequence homologous to a heat-shock element. In addition, several inverted repeats and palindrome sequences were involved in the 5' upstream region. Those suggest that the 5' flanking domain of RpIILS would be highly structured which may be responsible for transcriptional regulation.

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Year:  1995        PMID： 7622068     DOI： 10.1016/0378-1119(95)00081-g

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  5 in total

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  5 in total

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