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Literature DB >> 762087

The biosynthetic route from ornithine to proline.

L J Mestichelli, R N Gupta, I D Spenser.

Abstract

It is shown by tracer experiments with DL-[2-3H,5-14C]- and DL-[(RS)-5-3H,5-14C]rnithine, that the metabolic conversion of ornithine into proline, in three plant species (Nicotiana tabacum, Datura stramonium, and Lupinus angustifolius), takes place with maintenance of the delta-hydrogen atoms but with loss of the alpha-hydrogen atom. This indicates a route via alpha-keto-delta-aminovaleric acid (5-amino-2-oxopentanoic acid) and disproves the accepted route via glutamic gamma-semialdehyde (2-amino-5-oxopentanoic acid).

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Year: 1979 PMID： 762087

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

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Cited

17 in total

1. Mitochondrial transport in proline catabolism in plants: the existence of two separate translocators in mitochondria isolated from durum wheat seedlings.

Authors: Catello Di Martino; Roberto Pizzuto; Maria Luigia Pallotta; Aurelio De Santis; Salvatore Passarella
Journal: Planta Date: 2005-12-02 Impact factor: 4.116

2. Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.

Authors: André Hallen; Arthur J L Cooper; Joanne F Jamie; Peter Karuso
Journal: Neurochem Res Date: 2015-05-01 Impact factor: 3.996

3. Isolation of the ornithine-delta-aminotransferase cDNA and effect of salt stress on its expression in Arabidopsis thaliana.

Authors: N H Roosens; T T Thu; H M Iskandar; M Jacobs
Journal: Plant Physiol Date: 1998-05 Impact factor: 8.340

Review 4. Compartmental and regulatory mechanisms in the arginine pathways of Neurospora crassa and Saccharomyces cerevisiae.

Authors: R H Davis
Journal: Microbiol Rev Date: 1986-09

5. The reaction of ornithine aminotransferase with ornithine.

Authors: J A Williams; G Bridge; L J Fowler; R A John
Journal: Biochem J Date: 1982-01-01 Impact factor: 3.857

6. Studies on the pathway from ornithine to proline in cultured skin fibroblasts with reference to the defect in hyperornithinaemia with hyperammonaemia and homocitrullinuria.

Authors: R G Gray; S E Hill; R J Pollitt
Journal: J Inherit Metab Dis Date: 1983 Impact factor: 4.982

The biosynthetic route from ornithine to proline.

1. Mitochondrial transport in proline catabolism in plants: the existence of two separate translocators in mitochondria isolated from durum wheat seedlings.

2. Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.

3. Isolation of the ornithine-delta-aminotransferase cDNA and effect of salt stress on its expression in Arabidopsis thaliana.

Review 4. Compartmental and regulatory mechanisms in the arginine pathways of Neurospora crassa and Saccharomyces cerevisiae.

5. The reaction of ornithine aminotransferase with ornithine.

6. Studies on the pathway from ornithine to proline in cultured skin fibroblasts with reference to the defect in hyperornithinaemia with hyperammonaemia and homocitrullinuria.

7. Genetic and biochemical implications of the endosymbiotic origin of the chloroplast.

8. Metabolism of Proline, Glutamate, and Ornithine in Proline Mutant Root Tips of Zea mays (L.).

Review 9. Imine reductases: a comparison of glutamate dehydrogenase to ketimine reductases in the brain.

10. Properties of crystalline L-ornithine: alpha-ketoglutarate delta-aminotransferase from Bacillus sphaericus.