Literature DB >> 7620820

Inhibitory effect of FUT-175 on the production of interleukin 8 and polymorphonuclear leukocyte elastase.

M Kikuchi1, S Endo, K Inada, H Yamashita, T Takakuwa, H Nakae, T Kasai, N Baba, Y Yamada.   

Abstract

We investigated the inhibitory effects of a protease inhibitor, FUT-175, on the production of interleukin 8 (IL-8) and polymorphonuclear leukocyte elastase (PMNE) by polymorphonuclear leukocytes (PMN) and vascular endothelial cells. IL-8 production by PMN and vascular endothelial cells stimulated with lipopolysaccharide (LPS) was inhibited by FUT-175. This compound also inhibited PMNE production by PMN following LPS stimulation.

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Year:  1995        PMID： 7620820

Source DB:  PubMed          Journal:  Res Commun Mol Pathol Pharmacol        ISSN： 1078-0297


  2 in total

1.  Protective effects of nafamostat mesilate on liver injury induced by lipopolysaccharide in rats: possible involvement of CD14 and TLR-4 downregulation on Kupffer cells.

Authors:  Hideaki Miyaso; Yoshinori Morimoto; Michitaka Ozaki; Sanae Haga; Susumu Shinoura; Yasuhiro Choda; Hiroshi Murata; Goutaro Katsuno; Kamul Huda; Hideo Takahashi; Noriaki Tanaka; Hiromi Iwagaki
Journal:  Dig Dis Sci       Date:  2006-10-28       Impact factor: 3.199

2.  The role of nafamostat mesilate as a regional anticoagulant during extracorporeal membrane oxygenation.

Authors:  Jae Ha Lee; Jin Han Park; Ji Hoon Jang; Se Hun Kim; Sung Yong Hong; Woon Heo; Dong-Hwan Lee; Hye Sook Choi; Ki Hoon Kim; Hang-Jea Jang
Journal:  Acute Crit Care       Date:  2022-04-20
  2 in total

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