Literature DB >> 7617814

The glycine/NMDA receptor antagonist, L-701,324 reverses isolation-induced deficits in prepulse inhibition in the rat.

L J Bristow1, L Landon, K L Saywell, M D Tricklebank.   

Abstract

Previous studies have demonstrated that the glycine/NMDA receptor antagonist, L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)quinolone) blocks the activation of mesolimbic dopamine systems induced following psychostimulant administration in the rat (Bristow et al. 1994). In the present study, pretreatment with L-701,324 also reversed the deficit in prepulse inhibition (PPI) observed in rats reared in social isolation after weaning. Given that PPI is also attenuated in schizophrenic patients and that isolation rearing induces both neurochemical and behavioural abnormalities suggestive of a physiologically induced state of dopaminergic hyperactivity, these results suggest that blockade of the glycine/NMDA receptor may offer a new strategy for the development of novel antipsychotic agents.

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Year:  1995        PMID： 7617814     DOI： 10.1007/BF02245847

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  11 in total

Review 1.  Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia.

Authors:  A A Grace
Journal:  Neuroscience       Date:  1991       Impact factor: 3.590

Review 2.  Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients.

Authors:  N R Swerdlow; D L Braff; N Taaid; M A Geyer
Journal:  Arch Gen Psychiatry       Date:  1994-02

3.  The glycine/NMDA receptor antagonist, R-(+)-HA-966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK-801) in rodents.

Authors:  L J Bristow; P H Hutson; L Thorn; M D Tricklebank
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

4.  Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry.

Authors:  G H Jones; T D Hernandez; D A Kendall; C A Marsden; T W Robbins
Journal:  Pharmacol Biochem Behav       Date:  1992-09       Impact factor: 3.533

5.  3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex.

Authors:  M Rowley; P D Leeson; G I Stevenson; A M Moseley; I Stansfield; I Sanderson; L Robinson; R Baker; J A Kemp; G R Marshall
Journal:  J Med Chem       Date:  1993-10-29       Impact factor: 7.446

6.  R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine.

Authors:  P H Hutson; L J Bristow; L Thorn; M D Tricklebank
Journal:  Br J Pharmacol       Date:  1991-08       Impact factor: 8.739

7.  Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pump.

Authors:  S W Johnson; V Seutin; R A North
Journal:  Science       Date:  1992-10-23       Impact factor: 47.728

8.  Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat.

Authors:  R S Mansbach; M A Geyer
Journal:  Neuropsychopharmacology       Date:  1989-12       Impact factor: 7.853

9.  Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle.

Authors:  V A Keith; R S Mansbach; M A Geyer
Journal:  Biol Psychiatry       Date:  1991-09-15       Impact factor: 13.382

10.  Intra-accumbens infusion of quinpirole impairs sensorimotor gating of acoustic startle in rats.

Authors:  F J Wan; N R Swerdlow
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530
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  11 in total

1.  Developmental markers of psychiatric disorders as identified by sensorimotor gating.

Authors:  Susan B. Powell; Mark A. Geyer
Journal:  Neurotox Res       Date:  2002 Aug-Sep       Impact factor: 3.911

2.  Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats: an update.

Authors:  J Cilia; P D Hatcher; C Reavill; D N C Jones
Journal:  Psychopharmacology (Berl)       Date:  2005-01-14       Impact factor: 4.530

3.  Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs.

Authors:  G B Varty; G A Higgins
Journal:  Psychopharmacology (Berl)       Date:  1995-11       Impact factor: 4.530

4.  Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site.

Authors:  J N Kew; A Koester; J L Moreau; F Jenck; A M Ouagazzal; V Mutel; J G Richards; G Trube; G Fischer; A Montkowski; W Hundt; R K Reinscheid; M Pauly-Evers; J A Kemp; H Bluethmann
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

5.  An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.

Authors:  Jennifer E Murray; Andrew W Walker; Robert J Polewan; Rick A Bevins
Journal:  Psychopharmacology (Berl)       Date:  2010-09-22       Impact factor: 4.530

6.  The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats.

Authors:  Katherine L Nicholson; Robert L Balster
Journal:  Psychopharmacology (Berl)       Date:  2009-01-28       Impact factor: 4.530

7.  The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice.

Authors:  Masaki Sakaue; Yukio Ago; Akemichi Baba; Toshio Matsuda
Journal:  Psychopharmacology (Berl)       Date:  2003-05-27       Impact factor: 4.530

8.  Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801.

Authors:  Nobuhisa Kanahara; Eiji Shimizu; Shintaro Ohgake; Yuko Fujita; Mami Kohno; Tasuku Hashimoto; Daisuke Matsuzawa; Yukihiko Shirayama; Kenji Hashimoto; Masaomi Iyo
Journal:  Psychopharmacology (Berl)       Date:  2008-04-24       Impact factor: 4.530

9.  Subchronic treatment with kynurenine and probenecid: effects on prepulse inhibition and firing of midbrain dopamine neurons.

Authors:  L K Nilsson; K R Linderholm; S Erhardt
Journal:  J Neural Transm (Vienna)       Date:  2005-08-05       Impact factor: 3.850

10.  Role of the NMDA-receptor in Prepulse Inhibition in the Rat.

Authors:  Klas Linderholm; Susan Powell; Elin Olsson; Maria Holtze; Ralph Snodgrass; Sophie Erhardt
Journal:  Int J Tryptophan Res       Date:  2010-02-12
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