| Literature DB >> 7617032 |
M R Walter1, W T Windsor, T L Nagabhushan, D J Lundell, C A Lunn, P J Zauodny, S K Narula.
Abstract
The crystal structure of interferon-gamma bound to the extracellular fragment of its high-affinity cell-surface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-gamma homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-gamma receptors do not interact with one another and are separated by 27 A. Upon receptor binding, the flexible AB loop of interferon-gamma undergoes a conformational change that includes the formation of a 3(10) helix.Entities:
Mesh：
Substances：
Year: 1995 PMID： 7617032 DOI： 10.1038/376230a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962