Literature DB >> 761421

Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6.

E Bakker, P L Pearson, P Meera Khan, G M Schreuder, K Madan.   

Abstract

Linkage analysis of the data obtained from a three-generation Dutch family segregating for genetic variants of centromeric heterochromatic region in the band p11 on chromosome 6 (6ph), major histocompatibility (MHC) genes HLA-A, HLA-B and HLA-C, glyoxalase I (GLO) and phosphoglucomutase-3 (PGM3) showed that the genetic distance between the HLA gene cluster and 6ph is about 6 cM (at an estimated peak lod score of 3.466), that GLO is closer than HLA to the centromere and that PGM3 is probably not situated on the same chromosomal arm as HLA.

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Year:  1979        PMID： 761421     DOI： 10.1111/j.1399-0004.1979.tb01762.x

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  5 in total

Review 1.  The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.

Authors:  P J Thornalley
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857

2.  Construction of a map of the short arm of human chromosome 6.

Authors:  R Leach; R DeMars; S Hasstedt; R White
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  Reactivation by a trans-acting factor of human major histocompatibility complex Ia gene expression in interspecies hybrids between an Ia-negative human B-cell variant and an Ia-positive mouse B-cell lymphoma.

Authors:  R S Accolla; G Carra; J Guardiola
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

4.  Linkage relationships of biochemical markers to Q- and C-band variants in a large black kindred.

Authors:  T A Fogle; K K Namboodiri; R C Elston; W H McKenzie; C G Hames
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

5.  Mapping the locus for hereditary hemochromatosis: localization between HLA-B and HLA-A.

Authors:  C Q Edwards; L M Griffen; M M Dadone; M H Skolnick; J P Kushner
Journal:  Am J Hum Genet       Date:  1986-06       Impact factor: 11.025
  5 in total

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