Literature DB >> 7614012

DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat.

I E Hill1, J P MacManus, I Rasquinha, U I Tuor.   

Abstract

DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cortex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examined, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.

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Year:  1995        PMID： 7614012     DOI： 10.1016/0006-8993(95)00145-g

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  19 in total

1.  Effect of post-hypoxic reoxygenation on DNA fragmentation in cortical neuronal nuclei of newborn piglets.

Authors:  Jeffrey Parker; Qazi M Ashraf; Waseem Akhter; Om P Mishra; Maria Delivoria-Papadopoulos
Journal:  Neurosci Lett       Date:  2006-12-15       Impact factor: 3.046

2.  Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury.

Authors:  A G Yakovlev; S M Knoblach; L Fan; G B Fox; R Goodnight; A I Faden
Journal:  J Neurosci       Date:  1997-10-01       Impact factor: 6.167

3.  Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.

Authors:  Y Cheng; M Deshmukh; A D'Costa; J A Demaro; J M Gidday; A Shah; Y Sun; M F Jacquin; E M Johnson; D M Holtzman
Journal:  J Clin Invest       Date:  1998-05-01       Impact factor: 14.808

4.  BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway.

Authors:  B H Han; D M Holtzman
Journal:  J Neurosci       Date:  2000-08-01       Impact factor: 6.167

5.  Down-regulation of phospholipase D2 mRNA in neonatal rat brainstem and cerebellum after hypoxia-ischemia.

Authors:  Jeng-Hsiung F Peng; Yangzheng Feng; Philip G Rhodes
Journal:  Neurochem Res       Date:  2006-10-06       Impact factor: 3.996

6.  Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.

Authors:  K Fukuyama; R Iwakiri; T Noda; M Kojima; H Utsumi; S Tsunada; H Sakata; A Ootani; K Fujimoto
Journal:  Dig Dis Sci       Date:  2001-03       Impact factor: 3.199

7.  Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.

Authors:  Y M Kim; H T Chung; S S Kim; J A Han; Y M Yoo; K M Kim; G H Lee; H Y Yun; A Green; J Li; R L Simmons; T R Billiar
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

8.  Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis.

Authors:  G T Gobbel; M Bellinzona; A R Vogt; N Gupta; J R Fike; P H Chan
Journal:  J Neurosci       Date:  1998-01-01       Impact factor: 6.167

9.  Hypoxia differentially reduces GABA(A) receptor density during embryonic chick optic lobe development.

Authors:  D J Rodríguez Gil; C Carmona; G Negri; S Fiszer de Plazas
Journal:  Neurochem Res       Date:  2004-04       Impact factor: 3.996

10.  Unilateral blood flow decrease induces bilateral and symmetric responses in the immature brain.

Authors:  Sonia Villapol; Philippe Bonnin; Sébastien Fau; Olivier Baud; Sylvain Renolleau; Christiane Charriaut-Marlangue
Journal:  Am J Pathol       Date:  2009-10-08       Impact factor: 4.307
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