Literature DB >> 7613096

Telomeres and telomerase in aging and cancer.

C B Harley1, B Villeponteau.   

Abstract

Telomeres are maintained by the novel ribonucleoprotein enzyme telomerase. Telomerase activity is repressed in most somatic human cells, leading to telomere loss during replicative aging in vivo and in vitro. However, telomerase appears to be reactivated in essentially all human cancers. With the recent cloning of the RNA component of telomerase from several species, the stage is now set for critical tests of the role of telomeres and telomerase in aging and cancer.

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Year:  1995        PMID： 7613096     DOI： 10.1016/0959-437x(95)80016-6

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  59 in total

1.  Establishment of novel human esophageal cancer cell line in relation to telomere dynamics and telomerase activity.

Authors:  Y Kiyozuka; A Asai; D Yamamoto; H Senzaki; S Yoshioka; H Takahashi; K Hioki; A Tsubura
Journal:  Dig Dis Sci       Date:  2000-05       Impact factor: 3.199

2.  Immortalization of mammary cells from estrogen receptor alpha knock-out and wild-type mice.

Authors:  S O Mueller; H Tahara; J C Barrett; K S Korach
Journal:  In Vitro Cell Dev Biol Anim       Date:  2000 Nov-Dec       Impact factor: 2.416

3.  Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei.

Authors:  V Uhlmann; M Prasad; I Silva; K Luettich; L Grande; L Alonso; M Thisted; K J Pluzek; J Gorst; M Ring; M Sweeney; C Kenny; C Martin; J Russell; N Bermingham; M O'Donovan; O Sheils; J J O'Leary
Journal:  Mol Pathol       Date:  2000-02

4.  Multiple four-stranded conformations of human telomere sequence d(CCCTAA) in solution.

Authors:  K Kanaori; N Shibayama; K Gohda; K Tajima; K Makino
Journal:  Nucleic Acids Res       Date:  2001-02-01       Impact factor: 16.971

5.  Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining.

Authors:  Alan K Meeker; Wesley R Gage; Jessica L Hicks; Inpakala Simon; Jonathan R Coffman; Elizabeth A Platz; Gerrun E March; Angelo M De Marzo
Journal:  Am J Pathol       Date:  2002-04       Impact factor: 4.307

6.  Growth inhibition of human glioma cells by transfection-induced P21 and its effects on telomerase activity.

Authors:  K Harada; K Kurisu; T Sadatomo; H Tahara; E Tahara; T Ide; E Tahara
Journal:  J Neurooncol       Date:  2000-03       Impact factor: 4.130

7.  Increased placental telomerase mRNA in hypertensive disorders of pregnancy.

Authors:  Ossie Geifman-Holtzman; Yali Xiong; Eliezer J Holtzman; Barbara Hoffman; John Gaughan; Dan A Liebermann
Journal:  Hypertens Pregnancy       Date:  2010       Impact factor: 2.108

Review 8.  Alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas.

Authors:  Xiaolei Ren; Chao Tu; Zhenchu Tang; Ruofei Ma; Zhihong Li
Journal:  Oncol Lett       Date:  2018-03-22       Impact factor: 2.967

9.  Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

Authors:  N P Weng; B L Levine; C H June; R J Hodes
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-21       Impact factor: 11.205

10.  Age related decrease of NOR activity in bone marrow metaphase chromosomes from healthy individuals.

Authors:  E Pedrazzini; N Mamaev; I Slavutsky
Journal:  Mol Pathol       Date:  1998-02
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