Literature DB >> 7612876

A fibroblast growth factor binding protein in human cerebral spinal fluid.

A Hanneken1, S Frautschy, D Galasko, A Baird.   

Abstract

A soluble protein which binds basic fibroblast growth factor (FGF-2) has been detected in cerebral spinal fluid from normal individuals and patients with Alzheimer's disease and Parkinson's disease. This 70-85 kDa protein is recognized by an antibody to the extracellular domain of the high affinity FGF receptor and is not detected by an antibody to the intracellular domain of the FGF receptor, suggesting that it consists of a truncated portion of the extracellular domain of the high affinity FGF receptor. This FGF-BP appears to be identical to the two IgG-like loop form of FGFR-1 identified and purified from human and bovine blood. The possibility that this FGF-BP may play a role in transporting, sequestering, or even delivering the FGFs to target cells in the CNS is discussed.

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Year:  1995        PMID： 7612876     DOI： 10.1097/00001756-199504190-00015

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  10 in total

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Authors:  R G Thorne; W H Frey
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 6.447

2.  Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor.

Authors:  J P Wagner; I B Black; E DiCicco-Bloom
Journal:  J Neurosci       Date:  1999-07-15       Impact factor: 6.167

3.  Cerebrospinal fluid stimulates leptomeningeal and meningioma cell proliferation and activation of STAT3.

Authors:  Mahlon D Johnson; Mary O'Connell; Michael Facik; Paul Maurer; Babak Jahromi; Webster Pilcher
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4.  The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs.

Authors:  Sujata G Pandit; Prasanthi Govindraj; Joachim Sasse; Peter J Neame; John R Hassell
Journal:  Biochem J       Date:  2002-01-15       Impact factor: 3.857

5.  Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.

Authors:  Yan-Bin XiYang; You-Cui Wang; Ya Zhao; Jin Ru; Bing-Tuan Lu; Yue-Ning Zhang; Nai-Chao Wang; Wei-Yan Hu; Jia Liu; Jin-Wei Yang; Zhao-Jun Wang; Chun-Guang Hao; Zhong-Tang Feng; Zhi-Cheng Xiao; Wei Dong; Xiong-Zhi Quan; Lian-Feng Zhang; Ting-Hua Wang
Journal:  Mol Neurobiol       Date:  2015-01-10       Impact factor: 5.590

Review 6.  New insights into the role of fibroblast growth factors in Alzheimer's disease.

Authors:  Ramy Alam; Yara Mrad; Hussein Hammoud; Zahraa Saker; Youssef Fares; Elias Estephan; Hisham F Bahmad; Hayat Harati; Sanaa Nabha
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Review 7.  A geroscience motivated approach to treat Alzheimer's disease: Senolytics move to clinical trials.

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Review 8.  Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis.

Authors:  Pratiek N Matkar; Ramya Ariyagunarajah; Howard Leong-Poi; Krishna K Singh
Journal:  Biomolecules       Date:  2017-10-02

9.  Constitutive and Regulated Shedding of Soluble FGF Receptors Releases Biologically Active Inhibitors of FGF-2.

Authors:  Anne Hanneken; Maluz Mercado; Pamela Maher
Journal:  Int J Mol Sci       Date:  2021-03-08       Impact factor: 5.923

Review 10.  Neurotrophic factors in Alzheimer's disease: role of axonal transport.

Authors:  K Schindowski; K Belarbi; L Buée
Journal:  Genes Brain Behav       Date:  2008-02       Impact factor: 3.449
  10 in total

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