Literature DB >> 7612074

Cytoplasmic oxytocin and vasopressin gene transcripts decline postpartum in the hypothalamus of the lactating rat.

R S Crowley1, T R Insel, J A O'Keefe, J A Amico.   

Abstract

Oxytocin (OT) and vasopressin (AVP) gene expression are enhanced in the rat hypothalamus in late gestation and during the second and third weeks of lactation. We report that during the first 3 postpartum days, OT and AVP cytoplasmic mRNAs in the supraoptic and paraventricular nuclei of lactating rats decreased dramatically, reaching less than one fifth of peak gestational levels by day 2 postpartum. Differences in the temporal pattern of OT and AVP expression were observed in the supraoptic and paraventricular nuclei from days 4-10 of lactation. We also compared OT and AVP cytoplasmic mRNAs isolated from the hypothalamus of day 3 lactating rats to cohorts that had litters removed at the time of parturition. Lactating rats had significantly lower OT and AVP cytoplasmic mRNA levels than their nonlactating cohorts. We further compared OT and AVP cytoplasmic mRNAs in the hypothalamus of day 12 lactating rats that had been ovariectomized or sham ovariectomized on day 3 of lactation. Ovariectomized day 12 lactating animals had significantly lower OT and AVP cytoplasmic mRNA levels than their intact cohorts. These data refute the hypothesis that lactation is characterized by persistently elevated hypothalamic cytoplasmic OT and AVP mRNAs produced as a result of continuous stimulation by suckling and suggest that ovarian steroids may exert a modulatory effect on hypothalamic OT and AVP expression during early lactation.

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Year:  1993        PMID: 7612074     DOI: 10.1210/endo.133.6.7612074

Source DB:  PubMed          Journal:  Endocrinology        ISSN: 0013-7227            Impact factor:   4.736


  9 in total

1.  Enhanced neurotransmitter release at glutamatergic synapses on oxytocin neurones during lactation in the rat.

Authors:  J E Stern; S Hestrin; W E Armstrong
Journal:  J Physiol       Date:  2000-07-01       Impact factor: 5.182

2.  The effects of short photoperiod, pinealectomy, and melatonin treatment on oxytocin synthesis and release in the male syrian hamster.

Authors:  M Juszczak; R W Steger; L Debeljuk; C Fadden; J N Rao; K E Borg; A Bartke
Journal:  Endocrine       Date:  1996-06       Impact factor: 3.633

3.  Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats.

Authors:  Benjamin C Nephew; Robert S Bridges
Journal:  Physiol Behav       Date:  2008-06-04

4.  Rapid estradiol-17beta modulation of opioid actions on the electrical and secretory activity of rat oxytocin neurons in vivo.

Authors:  Colin H Brown; Paula J Brunton; John A Russell
Journal:  Neurochem Res       Date:  2007-10-25       Impact factor: 3.996

5.  Lactation as a model for naturally reversible hypercorticalism plasticity in the mechanisms governing hypothalamo-pituitary- adrenocortical activity in rats.

Authors:  D Fischer; V K Patchev; S Hellbach; A H Hassan; O F Almeida
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

6.  Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats.

Authors:  Benjamin C Nephew; Robert S Bridges
Journal:  Pharmacol Biochem Behav       Date:  2008-06-29       Impact factor: 3.533

7.  Vasopressin, oxytocin, corticotrophin-releasing factor, and sodium responses during fluoxetine administration in the rat.

Authors:  I E Marar; J A Amico
Journal:  Endocrine       Date:  1998-02       Impact factor: 3.633

Review 8.  Autism, oxytocin and interoception.

Authors:  E Quattrocki; Karl Friston
Journal:  Neurosci Biobehav Rev       Date:  2014-09-30       Impact factor: 8.989

9.  Effects of Chronic Central Arginine Vasopressin (AVP) on Maternal Behavior in Chronically Stressed Rat Dams.

Authors:  Alexander J Coverdill; Megan McCarthy; Robert S Bridges; Benjamin C Nephew
Journal:  Brain Sci       Date:  2012-12
  9 in total

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